Aurora-A/STK-15 is a predictive factor for <Emphasis Type="Italic">recurrent</Emphasis> behaviour in non-invasive bladder carcinoma: a study of 128 cases of non-invasive neoplasms |
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Authors: | E Compérat P Camparo R Haus E Chartier-Kastler B Radenen F Richard F Capron V Paradis |
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Institution: | 1.Service Central d’Anatomie et Cytologie Pathologiques et d’Urologie,H?pital La Pitié-Salpêtrière,Paris,France;2.Faculté de Pharmacie,Unité CNRS, UMR 8149,Paris V,France;3.Service Central d’Anatomie et Cytologie Pathologiques et d’Urologie, Département d’Epidemiologie et de Santé Publique Nord,H?pital d’Instruction des Armées Val-de Grace,Paris,France;4.Service Central d’Anatomie et Cytologie Pathologiques,Groupe hospitalier Cochin-Saint Vincent de Paul, Faculté de médecine Paris V,Paris, Cedex 14,France |
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Abstract: | Aurora-A, a member of serine/threonine kinase, is implied in mitosis and centrosome maturation. Increasing levels of Aurora-A
have been shown to be present in several malignancies and especially in bladder cancer. No immunohistochemical marker has
shown to be able to predict the clinical outcome of patients with superficial bladder cancer, except MIB-1, as a predictive
marker of relapse and progression. The aim was to investigate the expression of Aurora-A and MIB-1 in tissue micro arrays
of superficial bladder cancer representative of pTa papillary urothelial neoplasm with different degrees of aggressiveness
(low malignant potential PUNLMP], non-invasive papillary urothelial carcinoma low grade NILGC], non-invasive papillary urothelial
carcinoma high grade NIHGC] and carcinoma in situ). We analysed predictive values of both markers, their specificity and
sensitivity in tumor recurrence. Aurora-A was a sensitive marker to predict tumor recurrence especially for pTa (PUNLMP, NILGC;
PUNLMP p < 0.001, NILGC p < 0.001) with statistical significant correlation between immunohistochemical staining and clinical outcome. MIB-1 expression
displayed statistical difference p = 0.002 in the PUNLMP group and p = 0.03 in the NILGC group. Aurora-A is a more sensitive marker than MIB-1 to predict relapse in pTa bladder neoplasias. The
combination of both markers seems to have a very powerful predictive value of recurrence (p < 0.001). |
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Keywords: | Aurora-A MIB-1 STK-6 Bladder cancer Superficial tumors |
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