细胞凋亡与子宫内膜异位症

子宫内膜异位症（EMs）发病原因尚未明了。EMs是妇科常见良性疾病,但却有增生、浸润、转移及复发等恶性行为,对其预防和治疗仍是目前难点。凋亡是基因控制的程序性细胞自我消亡过程,对机体维持自身稳态和组织器官正常生理功能至关重要。近年有资料表明,凋亡异常可促进EMs的发生发展。综述细胞凋亡途径,凋亡相关基因及凋亡在正常子宫内膜与EMs的在位、异位内膜中的不同表达,期望能操控细胞程序性死亡并应用于EMs的预防和治疗中。

Apoptosis and Endometriosis

The aetiology and pathogenesis of endometriosis remain obscure. Endometriosis is a commom gynecological disease, but it has some malignant behavors, such as hyperplasia, invasion, metastasis and recurrence. It is still a difficult problem for the preventation and treatment of endometriosis. Apoptosis is a distinctive form of programmed cell death, it plays a critical role in maintaining tissue homeostasis and represents a normal function to eliminate excess or dysfunctional cells. Accumulated evidence suggests that abnormal apoptosis can promote the occurrence and development of endometriosis. This study is a current review of the literature focused on the apoptosis pathways, expression of apoptosis in normal endometrium and the alterations in regulation of apoptosis in eutopic and ectopic endometrium from women with endometriosis. The role of apoptosis in the treatment of endometriosis is reviewed to link the basic research findings with clinical applications.