Adhesion molecules in untreated inflammatory arthritis: synovial expression and levels in synovial fluid and serum [corrected] [published erratum appears in QJM 1996 Jul;89(7):559] |
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Authors: | Mulherin DM; Veale DJ; Belch JJ; Bresnihan B; Fitzgerald O |
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Institution: | Department of Rheumatology, University College Dublin, Ireland. |
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Abstract: | Adhesion molecules play a critical role in regulating leucocyte migration
at sites of inflammation. The relationship of soluble forms in serum or
synovial fluid (SF) to synovial membrane expression in inflammatory
arthritis is controversial. We examined soluble intercellular adhesion
molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and
E-selectin levels in matched serum and SF, and their relationship to
expression in synovium obtained at the same time in 13 patients with
previously untreated inflammatory arthritis. Serum- soluble (s)ICAM-1
correlated with sedimentation rate (T = 0.45), Ritchie articular index (T =
0.47) and SF sICAM-1 (T = 0.48), and SF sICAM-1 correlated with membrane
ICAM-1 expression (p < 0.02). sE- selectin and sVCAM-1 levels were
unrelated to disease activity or membrane expression. Membrane E-selectin
expression correlated inversely with ICAM-1 expression (T = -0.57) and
serum sICAM-1 (T = - 0.54). Serum sE-selectin correlated inversely with
membrane ICAM-1 expression (T = -0.55). The correlations observed between
ICAM-1 in serum, SF, synovium and disease activity suggest that ICAM-1
could be a useful target for immunotherapy. The inverse relationship of
ICAM-1 and E-selectin suggest important differences in regulation and
pathogenetic roles.
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