| 肝炎病毒对造血干细胞移植的影响 |
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| 引用本文： | 姚志娟,王钧,张红宇,张文丽,孙丽华,孟庆祥,郭乃榄.肝炎病毒对造血干细胞移植的影响[J].临床血液学杂志,2010(2). |
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| 作者姓名： | 姚志娟 王钧 张红宇 张文丽 孙丽华 孟庆祥 郭乃榄 |
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| 作者单位： | 北京大学深圳医院血液科; |
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| 基金项目： | 深圳市科技计划项目(No:200701006) |
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| 摘 要： | 目的:探讨肝炎病毒对造血干细胞移植(HSCT)的影响。方法:回顾性分析我院21例肝炎病毒感染接受HSCT治疗的患者的临床资料。乙型肝炎病毒(HBV)感染18例,其中供受者同时有HBV感染4例,供者有HBV感染3例,受者有HBV感染11例,供者、受者移植前后服用拉米夫定预防和治疗HBV感染。丙型肝炎病毒(HCV)感染3例,均为受者感染,移植免疫恢复后给予α干扰素治疗。结果:HSCT后植活平均15(9～31)d。HSCT后发生急性移植物抗宿主病(GVHD)9例(47%),发生慢性GVHD7例(37%)。HSCT后无肝静脉闭塞症发生。HBV感染供者,HSCT后无爆发性乙型病毒性肝炎发生。1例(1/18)HBV感染患者HSCT后6个月停用拉米夫定而发生爆发性乙型病毒性肝炎。1例(1/18)受者HBsAg HBeAg HBcAb(+),供者HBsAb(+),HSCT3个月后患者HBsAb HBeAb HBcAb(+),HBV-DNA阴性。3例HCV感染患者HSCT后用α干扰素治疗,2例HCV-RNA转阴。结论:HBV感染的供受者,在行HSCT过程中,应用拉米夫定能够有效预防移植后乙型病毒性肝炎的复燃,丙型病毒性肝炎的患者应用干扰素治疗可使HCV-RNA转阴。初步认为,肝炎病毒感染可能并非是HSCT的禁忌症。
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| 关 键 词： | 肝炎病毒 造血干细胞移植 |
Effect of hepatitis virus infection on the outcome of hematopoietic stem cell transplantation |
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| YAO Zhijuan WANG Jun ZHANG Hongyu ZHANG Wenli SUN Lihua MENG Qingxiang GUO Nailan.Effect of hepatitis virus infection on the outcome of hematopoietic stem cell transplantation[J].Journal of Clinical Hematology,2010(2). |
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| Authors: | YAO Zhijuan WANG Jun ZHANG Hongyu ZHANG Wenli SUN Lihua MENG Qingxiang GUO Nailan |
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| Institution: | Department of Hematology/a>;Shenzhen Hospital/a>;Peking University/a>;Shenzhen/a>;518036/a>;China |
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| Abstract: | Objective:To explore the effect of hepatitis virus infection on the outcome of hematopoietic stem cell transplantation (HSCT).Method:A retrospective analysis was conducted at the bone marrow transplant unit in our hospital. A total of 72 patients underwent HSCT,among them there were 21 patients with hepatitis virus infection. There were 18 patients with HBV infection included in the study. Among 18 cases,11 infected cases were recipients,3 infected cases were donors,4 cases were donors and recipients simult... |
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| Keywords: | hepatitis virus hematopoietic stem cell transplantation |
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