降钙素原和C反应蛋白及白细胞计数对慢性阻塞性肺疾病急性加重患者感染的诊断价值

目的 探讨降钙素原（PCT） 和C反应蛋白（CRP）及白细胞计数（WBC）对慢性阻塞性肺疾病急性加重（AECOPD）患者发生感染的诊断价值.方法 选择2012年2月-2013年2月我院呼吸科住院好转出院的AECOPD患者120例,依据是否因感染诱发AECOPD分为感染组（n=83）和非感染组（n=37）.检测两组患者入院时和出院前1 d的血清CRP、PCT水平和WBC.结果 感染组入院时PCT、CRP水平和WBC均高于非感染组 （P＜0.05）.出院前1 d两组患者 PCT水平、WBC比较,差异均无统计学意义（P＞0.05）;但感染组CRP水平高于非感染组（P＜0.05）.结论 联合检测外周血中PCT、CRP水平和WBC有助于判断COPD患者是否因感染而急性加重,同时可以作为感染有效控制的参考指标.

Diagnostic Value of Procalcitonin,C-reactive Protein and White Blood Cell Count in Infection of Patients with Chronic Obstructive Pulmonary Disease in Acute Exacerbation

Objective To investigate the diagnostic value of proealeitonin （PCT）, C -reactive protein （CRP） and WBC in infection of patients with chronic obstructive pulmonary disease in acute exacerbation （AECOPD）. Methods 120 hos- pitalized patients with AECOPD who had improved curative effect and discharged were selected, and they were divided into infec- ted group （ n = 83） and non - infected group （ n = 37 ）. CRP, PCT and WBC were detected at admission and 1 d before discharge in the two groups. Results The levels of PCT, CRP and WBC in infected group were higher than those of non - infected group at admission （P 〈 0.05）. There was no statistically significant difference of PCT, WBC in the two groups 1 d before dis- charge （P 〉0. 05）, but the level of CRP in infected group was higher than that of non - infected group （P 〈0. 05）. Conclusion Combined detection of PCT, CRP and WBC in peripheral blood can help determine whether AECOPD related to infection or not, and can be used as a reference indicator of effectively control of infection.