新辅助化疗在宫颈癌治疗中的应用及临床价值分析

目的探讨新辅助化疗方案在宫颈癌治疗中的应用效果及临床价值。方法将116例Ⅰb2～Ⅱa期宫颈癌患者分为观察组（65例）和对照组（51例）,对照组患者采用手术治疗,观察组患者在术前给予紫杉醇联合顺铂辅助化疗方案。观察新辅助化疗的临床疗效及不良反应情况,并对两组患者手术及术后病理情况进行对比分析。结果观察组患者化疗总有效率为76.9%,主要不良反应为消化道反应及骨髓抑制,均为Ⅰ～Ⅱ级反应。两组患者术中出血量比较差异无统计学意义（P〉0.05）,但手术时间明显低于对照组（P〈0.05）。观察组患者切缘阳性率、淋巴结转移率及深层间质浸润率均明显低于对照组,差异有统计学意义（P〈0.05）。结论新辅助化疗方案用于宫颈癌患者中,可缩小肿瘤体积、降低肿瘤分期,对改善手术效果及患者预后均有积极意义。

Analysis of the application and clinical values of neoadjuvant chemotherapy on cervical cancer

Objective To explore the application effects and clinical values of neoadjuvant chemotherapy（ NACT） on the treatment of cervical cancer. Methods 116 cases of Phase Ib2 ～ IIa cervical cancer were divided into the observation group and the control group. The control group reveived surgery,while the observation group reveived paclitaxel combined with cisplatin chemotherapy before surgery. The clinical efficacy and adverse reactions of NACT were observed,and the operative and post-operative pathologic conditions were compared between both groups. Results The chemotherapy ORR of the observation group was 76. 9%. The main adverse reactions during the chemotherapy were gastrointestinal reactions and myelosuppression,both ranking mild reactions at Level I ～ II. There was no significant difference in intra-operative blood loss between the two groups（ P〈0. 05）. But the operative time of the observation group was significantly lower than that of the control group（ P〈0. 05）. The positive surgical margins,the metastatic lymph node ratio and the deep stromal infiltration rate of the observation group were all significantly lower than those of the control group（ P〈0. 05）. Conclusions On treatment of cervical cancer,NACT can reduce tumor size,lower tumor staging,and play an important role in improving the operation effect and prognosis of patients.