首发与复发抑郁症患者的过度概括化自传体记忆比较

目的探索复发性抑郁症与首发抑郁症患者过度概括化自传体记忆（OGM）的差异，以及过度概括化自传体记忆对抑郁症状的影响。方法对34例首发性抑郁症患者以及31例复发性抑郁症患者，采用自传体记忆测评（autobiographicalmemorytest，AMT）评定过度概括化自传体记忆水平、汉密尔顿抑郁量表测评（HAMD-17）及贝克抑郁量表（BDI）评定抑郁严重程度。结果①复发性抑郁症组OGM总分显著高于首发抑郁症组[分别为（3．90±1．65）分，（3．10±1．57）分，t=2．035，P〈O．05]；②复发性抑郁症组积极线索词诱导的OGM总分显著高于首发抑郁症组[分别为（2．40±1．36）分，（1．70±1．08）分，t=2．308，P〈0．05]；③OGM与BDI总分、HAMD总分以及认知障碍因子、迟缓因子呈高度的正相关性（r=0．497，P〈0．05；r=0．552，P〈0．05；r=0．631，P〈0．05；r=0．553，P〈O．05）。结论与首发性抑郁症患者相比，复发性抑郁症患者的OGM更为严重，抑郁症患者的OGM亦能够增加抑郁症的复发频率，加重认知障碍、迟缓症状。

Comparison of overgeneral autobiographical memory between first-episode and recurrent depressive patients

Object To explore the difference of overgeneral autobiographical memory （OGM） between first-episode and recurrent depressive patients, and whether the overgeneral autobiographical memory can affect the symptoms of depression or not. Methods 34 first-episode depression patients and 31 recurrent depression pa- tients were enrolled. All patients were measured by autobiographical memory test （ AMT）, Hamilton Depression Scale-17 （HAMD-17） and Beck depression rating scale（BDI）. Results （1）The OGM score was higher in recur- rent depressive group than that in first-episode group（ respectively, （3.90± 1.65）, （ 3.10± 1.57）, t= 2.035, P〈 0.05） .（2）The positive OGM score was higher in recurrent depressive group than that in first-episode group （respec- tively, （2.40±1.36）, （1.70±1.08）, t= 2.308, P〈0.05）.（3）The correlation coefficient （ r value）between the total score of OGM and total score of BDI,total score of ttAMD, two subfactors （cognitive disorder and slow）scores of HAMD in recurrent depressive group were 0.497,0.552,0.631, and 0.553 respectively ,which significantly correla- ted. Conclusion Compared with first-episode depressive patients, the OGM in recurrent depressive patients is more severe. The OGM can increase the symptoms of depression, the cognitive disorder and slow.