氟哌噻吨美利曲辛对老年急性冠脉综合症患者焦虑抑郁情绪及临床疗效的影响

目的观察氟哌噻吨美利曲辛对老年急性冠脉综合症（ACS）伴抑郁患者的临床疗效。方法将人选的88例老年ACS伴抑郁的患者随机分为氟哌噻吨美利曲辛组（n：43）和对照组（n=45），氟哌噻吨美利曲辛组在常规内科治疗基础上给予氟哌噻吨美利曲辛，每天早晨、中午各1片口服；对照组给予常规内科药物治疗。12周后观察两组SDA和SDS评分、主要心血管不良事件（MACE）发生率及心脏自主神经功能等情况。结果氟哌噻吨美利曲辛组的SDA和SDS评分较对照组明显下降（34．28±6．35）分，（52．68±5．74）分；（41．19±4．63）分，（54．68±4．32）分，P〈0．05]；主要心血管不良事件（MACE）发生率显著减少（4．6％，28．9％，P〈0．05）；氟哌噻吨美利曲辛组较对照组SDNN明显升高（109．03±23．08）ms，（98．29±27．44）md，P〈0．05]、LF显著降低（152．89±92．75）ms。，（249．21±64．17）ms2，P〈0．05]。结论氟哌噻吨美利曲辛可明显改善老年ACS伴抑郁患者的抑郁症状，通过改善心脏的自主神经功能，而减少严重心律失常的发作，改善患者的短期预后。

Effects of Deanxit on depression and clinical outcomes in elderly patients with acute coronary syn- drome

Objective To investigate deanxit clinical efficacy of depression in elderly patients with acute coronary syndrome（ACS）. Methods 88 elderly patients with ACS and depression were randomly divided into Deanxit （2 tablets daily ; Deanxit, n = 43 ） or placebo （ control, n = 45 ） treatment in addition to standard therapy. SDA score, SDS score, MACE and cardiac autonomic nerve function were performed at 12 weeks follow-up. Results In deanxit group,SDA score and SDS score were significantly reduced （34.28 ＋ 6.35 vs 52.68 ＋ 5.74,41.19 ＋ 4.63 vs 54.68 ＋4.32, P〈0.05） ,MACE were also decreased （4.6% vs 28.9%, P〈0.05）. SDNN were signifi- cantly higher than control （ 109.03 ＋ 23.08 vs 98.29 ＋ 27.44, P 〈 0.05 ）, but LF was reduced （ 152.89 ＋ 92.75 vs 249.21 ＋ 64.17, P〈 0.05）. Conclusion Deanxit can improve the depression and clinical symptoms in elderly patients with ACS and depression. By improving the cardiac autonomic nerve function, deanxit possible reduce the onset of severe arrhythmia and improve the short-term prognosis.