苏州地区儿童急性呼吸道感染鼻咽部病毒病原学分析

目的 分析苏州地区儿童急性呼吸道感染（ARTI）鼻咽部病毒病原学的特征,探讨其临床意义.方法 选择2010年11月-2012年2月于苏州市立医院本部儿科病房住院治疗的ARTI患儿367例,分别按性别、年龄及季节进行分组,采用直接荧光免疫法对患儿鼻咽部采样物进行呼吸道合胞病毒（RSV）、腺病毒（Adv）、流感病毒A（Flu A）、流感病毒B（Flu B）、副流感病毒1（PIV Ⅰ）、副流感病毒2（PIV Ⅱ）、副流感病毒3（PIV Ⅲ）检测.结果 367例ARTI患儿中检测出阳性结果有148例（40.33%）,按阳性率从高到低依次为RSV 112例（30.52%）、PIV Ⅲ 28例（7.63%）、Adv 10例（2.72%）、Flu A 4例（1.09%）、Flu B 3例（0.82%）.≤11个月患儿病毒阳性率和RSV阳性率均高于其他两个年龄段（P＜0.05）;冬季病毒阳性率和RSV阳性率均高于其他3个季节（P＜0.05）.结论 病毒感染是ARTI的主要病因之一,RSV和PIV Ⅲ是苏州地区儿童病毒感染的主要病原体,且婴幼儿和冬季病毒感染更为明显.

Viral Etiology of Nasopharynx in Children with Acute Respiratory Infections in Suzhou

Objective To analyze the viral etiology of nasopharynx in children with acute respiratory tract infection （ARTI） in Suzhou, to explore its clinical significance. Methods 367 children with ARTI hospitalized in the Department of Pediatrics, Suzhou Municipal Hospital were selected from November 2010 to February 2011, and divided by gender, age and seasons. Direct fluorescence immunoassay nasopharynx was used to test respiratory syncytial virus （RSV）, adenovirus （Adv）, ifluenze virus A （Flu A）, ifluenze virus B （Flu S）, parainfluenza virus I （PIV I ）, parainfluenza virus II （PIV 1I ）, parainfluenza virus m 〈 PIV m ） of the children＇s samples. Results A total of 367 samples were detected, and thereinto 148 samples were positive, with a detection rate of 40. 33%. The positive rate of RSV was 30. 52% （112 cases）, PIV m was 7.63% （28 cases）, Adv was 2. 72% （10 cases）, Flu A was 1.09% （4 cases）, Flu B was 0. 82% （3 cases）. The positive rate of virus and RSV in ~〈 11 months group were higher than those of other two age groups （ P 〈 0.05 ） ; higher in winter group than those of other three seasons （P 〈 0. 05）. Conclusion Virus infection is a major cause of ARTr, in which RSV and PIV m are major pathogen infection of children in Suzhou, infants and winter viral infections are much more obvious.