氨基酮戊酸光动力疗法治疗90例皮肤癌及癌前病变的临床观察

目的探讨氨基酮戊酸光动力疗法（ALA—PDT）治疗皮肤癌及癌前病变的临床价值。方法选取收治的90例皮肤癌患者行ALA—PDT治疗，观察评估其治疗效果和不良反应。结果治疗6个月后，完全反应67例（74．4％），部分反应17例（18．9％），无效6例（6．7％），复发13例（14．4％）。基底细胞癌、鳞状细胞癌、疣状癌、日光性角化、Bowen病、Paget病等皮肤癌及癌前病变的有效率和复发率分别为92．9％和14．3％、92．0％和16．0％、100％和14．3％、100％和12．5％、90．0％和10．0％、91．7％和16．7％，各疾病类型之间的有效率和复发率差异均无统计学意义（P〉0．05），且均未出现严重不良反应。结论ALA—PDT治疗皮肤癌及其癌前病变的效果满意、不良反应轻。

Clinical research on ALA-PDT in the treatment of 90 cases of skin cancer and precancerous lesions

Objective To investigate the clinical value of ALA-PDT in the treatment of skin cancer and precancerous lesions. Methods The 90 cases of patients admitted to hospital were treated with ALA- PDT treatment. The therapeutic effect and adverse reactions were observed and compared. Results After treatment 6 months,complete response in 67 cases （74.4%） ,partial response in 17 patients （ 18.9% ） ,ineffective in 6 cases （6. 7% ） ,recurrence in 13 cases （14. 4% ）. The total efficiency rate and recurrence rate of basal cell carcinoma, squamous cell carcinoma, verrucous carcinoma, solar keratoses, Bowen＇s disease, Paget＇s disease were 92. 9% and 14. 3% ,92. 0% and 16. 0% ,100% and 14. 3% ,100% and 12. 5% ,90. 0% and 10. 0% ,91.7% and 16. 7%. The total efficiency rate and recurrence rate between each type of disease was no significant difference （P 〉 0. 05） ; and there was no serious adverse reactions. Conclusions ALA- PDT has satisfactory effects in the treatment of skin cancer and precancerous lesions with lighter adverse reactions.