Efficacy of Emodepside plus Praziquantel Tablets (Profender? Tablets for Dogs) against Mature and Immature Cestode Infections in Dogs |
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| Authors: | Iris Schroeder Gertraut Altreuther Annette Schimmel Peter Deplazes Dawid J Kok Manuela Schnyder and Klemens J Krieger |
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| Institution: | (1) Department of Biological Sciences, Yarmouk University, Irbid, Jordan;(2) Cestode Zoonoses Research Group, School of Environmental and Life Sciences, University of Salford, Salford M5 4WT, UK |
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| Abstract: | The efficacy of a novel flavoured tablet formulation of emodepside plus praziquantel (Profender? tablets for dogs) against
intestinal cestodes was investigated in four randomised, blinded placebocontrolled dose confirmation studies in dogs experimentally
infected with Echinococcus granulosus or E. multilocularis and in dogs naturally infected with Dipylidium caninum or Taenia spp. The tablets were used at the minimum recommended dose of 1 mg emodepside and 5 mg praziquantel per kg body weight. The
studies demonstrated 100% efficacy against mature and immature E. granulosus and E. multilocularis and mature Taenia spp. and D. caninum. Additionally, one of the studies demonstrated non-interference of emodepside with the efficacy of praziquantel against D. caninum. No side effects of the treatment were observed. It is concluded that emodepside plus praziquantel tablets are safe and effective
against mature and immature stages of E. granulosus and E. multilocularis and mature stages of Taenia spp. and D. caninum. |
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