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Dominantly-inherited polycystic kidneys in infants: Association with hypertrophic pyloric stenosis |
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| Authors: | J P Loh J O Haller E G Kassner A Aloni K Glassberg |
| Institution: | (1) Department of Radiology of the State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Box 45, 11203 Brooklyn, New York, USA;(2) Department of Urology of the State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Box 45, 11203 Brooklyn, New York, USA;(3) Selden Medical Center, Selden, New York, New York, USA |
| Abstract: | Newborn male fraternal twins presented at 10 days of age with bilateral flank masses; intravenous urograms showed polycystic kidney disease. Both babies also had hypertrophic pyloric stenosis (HPS). Their father has radiographic and sonographic findings of previously unsuspected polycystic kidneys and has a history of HPS in infancy. The association of dominantly-inherited polycystic kidneys (DPK) and HPS in this family is probably due to chance. However the authors speculate that the autosomal gene for DPK may occur at one of several loci that carry the genetic liability for HPS, a disorder transmitted by polygenic inheritance. |
| Keywords: | Cystic disease kidneys Polycystic kidneys infants Polycystic kidneys adult type Hypertrophic pyloric stenosis inheritance |
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