自体造血干细胞移植治疗伴发四肢淀粉样变性的多发性骨髓瘤

为了探讨多发性骨髓瘤伴发淀粉样变性的罕见病例的有效治疗方法。对1例58岁的伴发四肢淀粉样变性的多发性骨髓瘤老年患者进行了包括血液免疫检查在内的多项实验室检查，骨髓穿刺和活检，以及全骨髓显象等检查，在治疗方面给予化疗药物治疗和自体造血干细胞移植。结果显示：自体造血干细胞移植后23天患者骨髓造血恢复，免疫固定电泳正常，骨髓穿刺浆细胞占0．6％。结论：自体造血干细胞移植是治疗伴发四肢淀粉样变性的多发性骨髓瘤的有效方法。

Auto-hematopoietic Stem Cell Transplantation for Multiple Myeloma Accompanied with Amyloidosis in Four Limbs

The study was aimed to investigate the effective therapeutic method for patients with multiple myeloma accompanied with amyloidosis. A 58-year-old patient diagnosed as multiple myeloma accompanied with amyloidosis in four limbs was enrolled in this study. The various clinical and laboratorial examinations were performed, including bone marrow smear, immunologic test, rodiograply and so on. Patient received chemotherapeutic drugs and then autologous hematopoietic stem cell transplantation （auto-HSCT）. The result showed that hematopoietic reconstitution was achieved at 23 days after auto-HSCT, lmmunofixation electrophoresis was normal. There was only 0.6% plasma cells in the bone marrow. In conclusion, the auto-HSCT may be an effective treatment for multiple myeloma accompanied with amyloidosis in four limbs.