| 脑康灵胶囊的急性和长期毒性试验 |
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| 引用本文： | 张煦,李文广.脑康灵胶囊的急性和长期毒性试验[J].兰州医学院学报,1998,24(1):19-21. |
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| 作者姓名： | 张煦 李文广 |
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| 作者单位： | 兰州医学院病理学教研室(张煦)，兰州医学院药理学教研室(李文广，吴勇杰) |
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| 摘 要： | 研究脑康灵胶囊的毒性。方法：采用一日耐受量法和长期毒性法。结果；脑康灵胶囊毒性极低，无法测得ＬＤ５０，小鼠一日最大耐受量为４０ｇ／ｋｇ体重，相当于人临床用药量的２００倍，本药３ｇ／ｋｇ，９ｇ／ｋｇ分别给大鼠灌胃１２０天，和对照比较，不影响大鼠生长发育，不影响造血功能，肝功能及肾功能。
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| 关 键 词： | 脑康灵胶囊 急性 毒性 长期 |
The acute and chronic toxicity test of Naokangling capsula(NKL) |
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| ZHANG Xu, et al.The acute and chronic toxicity test of Naokangling capsula(NKL)[J].Journal of Lanzhou Medical College,1998,24(1):19-21. |
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| Authors: | ZHANG Xu |
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| Abstract: | Objective:To study toxicity of NKL capsula.Methods: Maximal tolerance dose(ig) in one day chronic toxicitymethods were used. Results:The acute toxicic of NKL is too low to assay it' s LD50,it's maximal tolerance dose(ig) in oneday is 40g/kg that equals 200 times as people's alinic dose. NKL 3.9g/kg ig for 120 days didn't influence the growth andfunction of hematopoietic system,liver,renal of rat,the histological structure of all organa had no any change, but it couldenhance hemoglobin synthesis and thymus weight of rat. Conclusion: Had no any toxicity of NKL under tested dose. |
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| Keywords: | Naokangling capsula Acute toxicity Chronic toxicity |
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