颞叶癫痫海马、杏仁核及皮层病灶的超微结构观察

对１９例临床确认为颞叶癫痫而行海马杏仁核及皮层病灶切除术棘波灶的标本进行了电镜观察，发现在病变神经元周围，有髓神经纤维髓板松解、融合，轴突出芽；无髓神经纤维内微丝、微管排列紊乱，缠绕成团，见团样小体结构；突触中圆形突触小泡增多或耗竭。扁平状突触小泡相对较少；神经毡及毛细血管旁可见许多颗粒性电子致密物沉着，经Ｘ射线显微分析排除无机离子，考虑这些沉着物仍为机体的有机成份。半定量观察结果显示三个部位超微病理变化具有相似性。本课题的观察提示神经纤维及突触的病变可能是痫性活动的直接形态依据，而这种具有病变神经纤维及突触的神经元在痫性活动中则可能起着“起搏细胞”的作用，痫性活动的产生与兴奋性及抑制性递质的平衡失调有关。

Observation on spike foci of the hippocampus amygdala and cerebral cortices in human temporal lobe epilepsy with electron microscope

A study of the ultrastructure of epileptogenic spike foci including hippocampus, amygdala and cerebral cortices was carried out in 19 cases of patients through transmition electron microscopy. There were many changes in the area of diseasd neurons. The myelins of myelinated fiber were slackened and stuck together. The axons sprouted the new projectings, microtubules and microfibrils in unmyelinated fibers were arranged irregularly and twined each other, the ball like structure may be seen. The rounded synaptic vesicles were increased in number or exhausted and the flatted synaptic vesicles were rare relatively. many a granular electron dense substances deposited in the stroma. X ray microanalysis didn't exhibit the deposits of any inorganic cations and may be the deposits of some organic substances. By means of semi quantitative observation, three parts of ultrastructural appearance were similar to each other. Our research indicatets that the diseased nerve fibers and synapse may represent the direct morphologicalfacts associated with epileptic activities, while, the neurons which contained the diseased nerve fibers and synapse may act as the kindling role. The production of epileptic activity is related to those umbalance between excitative and inhibitive transmitters.