| 曲妥珠单抗在Her-2高表达胃癌治疗中的研究近况 |
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| 引用本文： | 章娟,吴洪斌,翟青. 曲妥珠单抗在Her-2高表达胃癌治疗中的研究近况[J]. 中国医院用药评价与分析, 2010, 0(5): 390-393 |
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| 作者姓名： | 章娟 吴洪斌 翟青 |
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| 作者单位： | 复旦大学附属肿瘤医院药剂科;复旦大学上海医学院肿瘤学系; |
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| 摘 要： | 目的：了解曲妥珠单抗（赫赛汀）在人表皮生长因子受体2（Her-2）高表达胃癌治疗中的研究近况。方法：对近年来曲妥珠单抗（赫赛汀）在Her-2高表达胃癌治疗中研究情况的文献资料进行分析,并对Her-2相关的检测方法进行探讨。结果：曲妥珠单抗（赫赛汀）在体内外能够抑制Her-2高表达胃癌细胞的生长,Ⅱ、Ⅲ期临床试验结果显示它能明显提高Her-2高表达胃癌患者的疗效和生活质量,显著延长生存时间。结论：曲妥珠单抗（赫赛汀）有望成为一种新型的治疗胃癌的生物靶向药物。
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| 关 键 词： | 曲妥珠单抗 表皮生长因子受体 胃癌 |
Rcent Progress in Research on Trastuzumab (Herceptin) Against Overexpression of Her-2 in Patients with Gastric Cancer |
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| ZHANG Juan,WU Hong-bin#,ZHAI Qing. Rcent Progress in Research on Trastuzumab (Herceptin) Against Overexpression of Her-2 in Patients with Gastric Cancer[J]. Evaluation and Analysis of Drug-Use in Hospital of China, 2010, 0(5): 390-393 |
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| Authors: | ZHANG Juan WU Hong-bin# ZHAI Qing |
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| Affiliation: | ZHANG Juan,WU Hong-bin#,ZHAI Qing (Dept. of Pharmacy,Fudan University Affiliated Tumor Hospital,Department of Oncology,Shanghai Medical College of Fudan University,Shanghai 200032,China) |
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| Abstract: | OBJECTIVE: To probe into the recent progress in research on Trastuzumab ( Herceptin) against overexpression of human epidermal growth factor receptor 2 (Her-2) in patients with gastric cancer. METHODS: The pertinent literature in recent years both at home and abroad about Trastuzumab ( Herceptin) against overexpression of Her-2 in patients with gastric cancer was reviewed,and the various testing methods of Her-2 were reviewed. RESULTS: Trastuzumab could inhibit the growth of Her-2 overexpressing cancerous c... |
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| Keywords: | Trastuzumab (Herceptin) Epidermal growth factor receptor Gastric cancer |
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