| 正常口腔黏膜和口腔鳞癌中人乳头瘤病毒感染率的研究进展 |
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| 引用本文： | 蒋倩,张志愿.正常口腔黏膜和口腔鳞癌中人乳头瘤病毒感染率的研究进展[J].上海口腔医学,2007,16(5):538-541. |
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| 作者姓名： | 蒋倩 张志愿 |
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| 作者单位： | 上海交通大学医学院附属第九人民医院·口腔医学院,口腔颌面外科,上海市口腔医学研究所,上海市口腔医学重点实验室,上海,200011;上海交通大学医学院附属第九人民医院·口腔医学院,口腔颌面外科,上海市口腔医学研究所,上海市口腔医学重点实验室,上海,200011 |
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| 基金项目： | 国家自然科学基金;上海市科学技术委员会重点实验室项目;上海市重点学科建设项目 |
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| 摘 要： | 黏膜高危型HPV-16、HPV-18感染是宫颈癌的主要致病因素,且与口腔鳞癌的发生密切相关,但目前对口腔鳞癌中HPV的感染率和亚型的分布尚不十分清楚。作者系统查阅了目前已经发表的有关HPV在正常口腔黏膜或口腔鳞癌中感染率和亚型分布的文献资料,对正常口腔黏膜、口腔鳞癌中人乳头瘤病毒的感染率的研究进展进行了综述。
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| 关 键 词： | 人乳头瘤病毒(HPV) 正常口腔黏膜 口腔鳞癌 聚合酶链反应(PCR) |
| 文章编号： | 1006-7248（2007）05-0538-04 |
| 收稿时间： | 2007-06-20 |
| 修稿时间： | 2007-08-13 |
The study of HPV prevalence in normal oral mucosa and oral squamous cell carcinoma |
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| JIANG Qian,ZHANG Zhi-yuan.The study of HPV prevalence in normal oral mucosa and oral squamous cell carcinoma[J].Shanghai Journal of Stomatology,2007,16(5):538-541. |
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| Authors: | JIANG Qian ZHANG Zhi-yuan |
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| Institution: | Department of Oral and Maxillofacial Surgery, Shanghai Research Institute of Stomatology, Ninth People's Hospital, College of Stomatology, School of Medicine, Shanghai Jiao Tong University, China. |
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| Abstract: | Mucosal infection with high-risk human papiloma virus(HPV) types 16 and 18 is the cause of cervical cancer and might be a subset of oral squamous cell carcinoma (OSCC), yet the prevalence and type distribution of HPV in oral SCC remained unclear. We systematically reviewed published studies of OSCC biopsies, which were employed to detect and genotype HPV through different methods .The aim of this investigation is to carry out a bibliographic review on the prevalence of HPV in OSCC and normal oral mucosa. Supported by Key Project of National Natural Science Foundation of China (Grant No.30630065), Key Lab Project of Science and Technology Committee of Shanghai Municipality (Grant No.06DZ22026) and Shanghai Leading Academic Discipline Project (Grant No. Y0203). |
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| Keywords: | Human papillomavirus(HPV) Normal oral mucosa Oral squamous cell carcinoma(OSCC) Polymerase chain reaction (PCR) |
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