脑梗死患者D-二聚体、超敏-CRP和一氧化氮测定的临床意义

目的探讨脑梗死患者血中D-二聚体（D-Dimer）、超敏C-反应蛋白（hs-CRP）、一氧化氮（NO）含量变化与脑梗死发生的关系。方法分别采用ELISA法、免疫散射比浊法和硝酸还原酶法测定D-Dimer、hs-CRP和NO含量。结果脑梗死组D，Dimer和hs．CRP含量明显高于对照组（P〈0．01）；脑梗死NO含量明显低于对照组（P〈0．01）；NO与D．Dimer（r=-0．50），P〈0．05和hs-CRP（r=-0．68。P〈0．01）含量经统计学处理呈负相关；D-Dimer和hs-CRP含量经统计学处理呈正相关（r=0．64，P〈0．01）；而且脑梗死面积大组D-Dimer和hs-CRP含量明显高于面积小组（P〈0．01）。结论血中D-二聚体、超敏C-反应蛋白、一氧化氦含量与脑梗死的发生及发展有密切关系。

Clinical significance of the concentration of D-Dimer, hs-CRP and NO in serum of patients with cerebral infarction

Objective To study the correlation between the levels of D-Dimer,high sensitive C-reaction and nitrogen monoxide in serum of patients with cerebral infarction.Methods The level s of D-Dimer,hs-CRP and NO were detected respectively in 48 patients with cerebral infarction and 48 healthy persons by ELISA,immunoturbidimitric assay and nitrate reducase method.Results Compared with healthy persons,the levels of D-Dimer and hs-CRP in serum of patients with cerebral infarction were significantly higher(P<0.01),and the level of NO in serum of patients with cerebral infarction were significantly lower(P<0.01).The level of NO was negatively correlated with that of D-Dimer and hs-CRP;The level of D-Dimer was positively correlated with that of hs-CRP;The levels of D-Dimer and hs-CRP in serum of patients with big infarction area were significantly higher than that patients with small infarction area.Conclusion The levels of D-Dimer,hs-CRP and NO closely related to the existence and development of cerebral infarction.