帕罗西汀与阿米替林治疗躯体形式障碍的随机双盲对照研究

目的:探讨帕罗西汀对躯体形式障碍的临床疗效及副反应。方法:采用随机分组的方法,将符合CCMD-3标准的60例躯体形式障碍患者分为帕罗西汀组(15例)、阿米替林组(15例),帕罗西汀组开放组(30例),治疗6周,用HAMD、HAMA、TESS、CGSSI评定疗效和副反应。结果:帕罗西汀与阿米替林组对躯体形式障碍的疗效差异无显著性(P>0.05)。治疗第4周末帕罗西汀组和帕罗西汀组开放组HAMD减分率和因子减分与阿米替林组比较差异有非常显著性(P<0.01)。副反应帕罗西汀组主要为口干、头晕、头痛。阿米替林组则为口干、便秘、头昏、头痛、视力模糊、嗜睡、血压升高。结论:帕罗西汀治疗躯体形式障碍有效,副反应轻微。

Comparison study of domestic paroxetine and amitriptyline in treatment of somatoform disorders randomized double-blind study

Objective: To study the clinical effects and side effects of paroxetine in treatment of somatoform disorders. Methods: Sixty patients who met CCMD - 3 for somatoform disorders were randomly assigned to paroxetine (15 patients), amitriptyline (15 patients) and open paroxetine (30 patients), treatment for 6 weeks. The clinical effects and side effects were tested with HAMD, HAMA, TESS and CGSSI. Results: Paroxetine was similar to amitriptyline in efficacy and there was no significant difference between three groups. Both groups showed significant improvement in scores of HAMD. The main side effects of paroxetine were dry mouth, headache, obscures vision and dizziness, and the main side effects of amitriptyline were dry mouth, constipation and the rising of blood pressure. Conclusions: Paroxetine is an effective drug with fewer side effects for the treatment of somatoform disorders.