Antiepileptic drug effects on somatosensory evoked potentials |
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| Institution: | 1. Department of Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;2. Department of Genetics, Yale University School of Medicine, New Haven, USA;3. Department of Basic Sciences, Universidade Federal de Juiz de Fora, Governador Valadares, Brazil;4. Laboratory of Clinical Genomics, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;5. Dept. of Pathology and Laboratory Medicine, The Children''s Hospital of Philadelphia, Philadelphia, USA;6. Children''s Mercy Hospital Research Institute, Kansas City, MO, USA;7. Department of Endocrinology, Hospital Felício Rocho, Belo Horizonte, Brazil;8. The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Tel-Hashomer, and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel;1. Department of Genetics, Zanjan Branch, Islamic Azad University, Zanjan, Iran;2. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran;3. Neurology Department, Ganjavian Hospital, Dezful University of Medical Sciences, Dezful, Iran;4. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;5. School of Medicine, Iran University of Medical Sciences, Tehran, Iran;6. Department of Neurology, School of Medicine, Imam Khomeini Hospital, Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran;1. Department of Obstetrics and Gynecology, Center for Reproductive Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei, China;2. Anhui Engineering Research Center for Low Temperature Medical Science and Artificial Organs, Hefei, China;3. National Research Institute for Family Planning, Beijing 100081, China;4. Graduate School of Peking Union Medical College, Beijing, China |
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| Abstract: | Some evoked potential changes have been documented in chronic phenytoin (PHT), valproate (VPA), or benzodiazepine therapy, whereas other studies have suggested little change with carbamazepine (CBZ) or phenobarbital (PB). We recorded median and posterior tibial nerve somatosensory evoked potentials (SEPs) in complex partial seizure patients taking PHT, CBZ, or VPA in monotherapy with stable therapeutic serum levels and no toxic symptoms. Ten patients each were studied with PHT, CBZ, and VPA and were compared with age-matched controls. Median nerve responses were recorded at Erb's point, cervical spine, and contralateral cerebral sites; tibial nerve evoked potentials were recorded from popliteal fossa, lumbar, cervical spine, and midline scalp electrodes. Epileptic patients and controls did not differ in SEP latency, amplitude, or central condition time. PHT prolonged Erb's point and popliteal fossa latencies, but not central conduction time. CBZ had no effect on latencies or amplitudes. Evoked potential amplitudes were reduced by VPA, and cortical response latencies were minimally prolonged. Chronic antiepileptic therapy without toxicity had little effect on SEPs. PHT may have a slight effect on peripheral nerve conduction, and VPA may have an effect on amplitude of cerebral responses. |
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