重症药疹53例临床分析

目的探讨重症药疹与致敏药物的关系以及重症药疹的防治。方法对本院2000年1月-2009年12月诊治的53例因重症药疹住院的患者临床资料进行回顾性分析。结果重症药疹最常见的致敏药是抗菌素、解热镇痛药、抗癫痫药和别嘌醇等。抗菌素、解热镇痛药引起的重症药疹预后较好，卡马西平、别嘌醇引起的重症药疹潜伏期长、预后较差。结论对重症药疹患者应及早使用足量糖皮质激素，加强支持疗法，这是稳定病情，降低死亡率的关键。

Clinical Analysis of 53 Cases with Severe Drug Eruption

Objective To investigate the relationship between clinical usage of drugs and severe drug eruption.Methods A retrospective analysis was carried out on the clinical data of all inpatients suffered with severe drug eruption admitted into our hospital during the ten years from Jan 2000 to Dec 2009.Results Severe drug eruptions are most often caused by antibiotics、nonsteroidal anti-inflammatory drugs(NSAIDs)、anti-epileptic drugs and allopurinol.The severe drug eruption caused by antibiotics、NSAIDs had favourable prognosis,while that caused by carhamazeping and allopurinol had longer latent period and bad prognosis.Canclusion It is important to give sufficient glucocorticoid earlier in the treatment of severe drug eruption,which may be helpful to control the disease and lower mortality rate.