药物治疗对内镜下食管静脉曲张套扎术后的远期影响

目的观察和评估药物治疗对食管静脉曲张套扎术后的影响。方法将99例食管静脉曲张患者随机分为治疗组(50例)和对照组(49例)，分别口服普萘洛尔和单硝酸异山梨酯及安慰剂，并于治疗后卜3个月、12—15个月使用胃镜观察。结果1—3个月治疗组在食管静脉曲张和门脉高压性胃病的程度、肝源性溃疡和消化道再出血的发生率与对照组相同，而12—15个月后治疗组在上述几个指标均比对照组低。结论食管静脉曲张套扎术后，通过长期的药物治疗能够缓解门脉高压所致的食管静脉曲张和门脉高压性胃病，降低肝源性溃疡的发生率，预防再出血。

Long-term efficacy of drugs for esophageal varices after ligation

Objective: To evaluate the long-term effection of drugs for esophageal varices after ligation. Methods: Ninety-nine patients with esophageal varices were randomized to two groups-treating group (50 cases) and control group(49 cases), to which oral proprolol / isosorbide mononitrate and matching placebo were given for (12~15) months respectively, then the patients were observed by endoscopy during (1~3) months and (12~15) months after ligation. Results: There was no remarkable difference between two groups on the extent of the varices and partal hypertensive astropathy(PHG), incidence of cirrhosis peptic ulcer and rebleeding during (1~3) months. After ligation. However, above indexes of treating group were remarkable lower than those of control group during (12~15) months after the ligation. Conclusion: Long-term treating with propranolol / isosorbide mononitrate is effective to cirrhosis after ligation. On reducing the extent of varices and PHG, incidence of cirrhosis peptic ulcer and rebleeding.