慢性肾脏病的单中心横断面流行病学研究

目的 调查单中心肾内科门诊慢性肾脏病(CKD)患者的基础状况,判断CKD患者肾功能下降的危险因素.方法 对门诊就诊的CKD患者进行为期9个月的前瞻性横断面调查.结果 共有780例CKD病例入选.前4位CKD的病因分别为原发性肾小球疾病(59.0%),高血压肾病(7.6%),狼疮肾炎(6.4%),糖尿病肾病(6.3%).病例平均年龄41.9岁.CKD各期的分布为CKD 1期47.8%、2期18.7%、3期14.0%、4期8.1%、5期11.4%.多因素回归提示年龄、蛋白尿、高血压与CKD患者的肾功能下降独立相关.结论 目前针对中国CKD患者最大规模的单中心横断面调查,有助于确定CKD患者的基本状况,为进一步纵向随访奠定基础.

Cross-sectional study of chronic kidney disease

Objective To present the baseline characteristics of serum uric acid level in patients with chronic kidney disease(CKD)in single.centre nephrology clinic and judge the risk factor for decreased renal function of CKD Datients.Methods A cross-sectional study on CKD patients in clinic was carried out for 9 months.Results 780 CKD cases were enrolled in the study.The top four causes of CKD in these patients were primary glomerular disease(59.0%),essential hypertension(7.6%),lupus nephritis(6.4%)and diabetic nephropathy(6.3%).The average age was 41.9.The distribution of CKD stage was 47.8%of CKD1,18.7%of CKD2,14.0%of CKD3,8.1% of CKD4 and 11.4%of CKD5.Multivariate Logistic regression regression analysis indicated that age,proteinuria,hypertension were independently correlated with decreased renal function.Conclusion This is the largest cross-sectional study of CKD in China,which will help to determine the basic status of Chinese CKD patients,laying a basis for further followup.