Clinical evaluation of a new oral cephem, cefpodoxime proxetil in children |
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| Authors: | H Meguro O Arimasu H Shiraishi T Tajima F Hiruma S Nishimura N Sugie K Sugamata T Abe R Fujii |
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| Affiliation: | Department of Pediatrics, School of Medicine, Teikyo University. |
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| Abstract: | Cefpodoxime proxetil (CPDX-PR, CS-807) was evaluated for its efficacy, safety and pharmacokinetics in children. CPDX-PR was effective in 93.6% of 47 cases with respiratory tract, middle ear, skin or urinary tract infections. Twice or 3 times daily administration of 3 mg/kg each was sufficient to treat streptococcal pharyngitis and Haemophilus influenzae infections. No severe adverse reaction was encountered in 52 cases treated with CPDX-PR. The serum half-life was approximately 2.17 +/- 0.24 hours after oral administration. |
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