Prognostic significance of surface markers expressed in multiple myeloma: CD56 and other antigens |
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Authors: | Sahara Naohi Takeshita Akihiro |
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Affiliation: | a Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu-shi, Japanb Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu-shi, Japan |
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Abstract: | Multiple myeloma (MM) is characterized by increased numbers of malignant plasma cells. Plasma cells, that represent the terminal differentiation of B lymphocytes, have considerable heterogeneity of surface markers expressed on them. Some studies showed the prognostic significance of several immunophenotypic molecules on MM cells. Here, we review several surface markers related to their prognostic significance in MM patients. We also report that CD56-negative MM is the unique entity characterized by poor prognosis with high incidence of extramedullary disease, Bence Jones protein, renal insufficiency, thrombocytopenia and plasmablastic morphology. |
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Keywords: | multiple myeloma surface markers prognosis CD56 heterogeneity |
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