血清甘氨酰脯氨酸二肽氨基肽酶对慢性肝病诊断的价值

观察血清甘氨酰脯氨酸二肽氨基肽酶 (GPDA)在慢性肝病中的变化 ,评价临床诊断价值。采用连续监测法测定 131例各类慢性肝病患者和 10 3名正常人血清GPDA活性 ,同步检测血清丙氨酸氨基转移酶 (ALT) ,进行比较分析。慢性肝炎轻度、中度、重度患者及原发性肝癌患者血清GPDA活性均高于正常对照组 ,差异有显著性意义(P均 <0 0 0 1) ,肝癌患者升高尤为显著 ;肝硬化代偿期和失代偿期患者GPDA水平与对照组无显著差异 (P >0 0 5 ) ;而ALT在慢性肝炎和肝硬化患者组均明显高于对照组 ,差异有非常显著性意义 (P均 <0 0 0 1) ,ALT升高的例数与倍数明显高于GPDA。血清GPDA对慢性肝炎的诊断及病情估计有一定的意义 ,但敏感性不如ALT。GPDA对肝硬化的诊断价值不大 ,但GPDA异常升高有助于肝癌的诊断

Significance of serum GPDA for diagnosis of chronic liver diseases

To study the variation of serum glycyl-proline dipeptidyl aminopeptidase(GPDA) in chronic liver diseases and to evaluate its clinical diagnosis value. Serum GPDA levels of 131 patients of chronic liver diseases and 103 normal control subjects were measured by continuous monitoring method. The levels of serum alanine aminotransferase (ALT) were measured simultaneously. The Serum GPDA levels of all kinds of chronic hepatitis and liver cancer patients were higher than those of control group and the difference between them was significant (P<0.001). The levels of GPDA of hepatocirrhosis patients with / without compensation and those of control group had no significant difference (P>0.05). The ALT levels of chronic hepatitis and hepatocirrhosis patients were higher obviously than those of control group and the difference between them was significant (P<0.001). The cases and times of ALT were higher than those of GPDA. There is some significance of serum GPDA for diagnosis of chronic hepatitis, but the sensitivity of GPDA is lower them that of ALT. There is some value of GPDA for diagnosis of liver cancer, but there is no value for diagnosis of hepatocirrhosis.