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| 甲状腺素对大鼠阴茎海绵体内NOS及CO含量影响的研究 | |
| 引用本文： | 胡存利,吴雅冬,刘洪涛,秦文波,王国政. 甲状腺素对大鼠阴茎海绵体内NOS及CO含量影响的研究[J]. 中华男科学杂志, 2009, 15(1): 37-40 |
| 作者姓名： | 胡存利 吴雅冬 刘洪涛 秦文波 王国政 |
| 作者单位： | 1. 佳木斯大学附属第一医院,泌尿外科,黑龙江,佳木斯,154002 2. 佳木斯大学附属第一医院妇产科,黑龙江,佳木斯,154002 3. 大庆油田总医院泌尿外科,黑龙江,大庆,163001 |
| 摘 要： | 目的:建立甲状腺功能亢进及甲状腺功能减退Wistar大鼠动物模型,检测其阴茎海绵体内NOS及内源性一氧化碳(CO)的含量,探讨甲状腺素对大鼠勃起功能的影响及内源性CO在阴茎海绵体勃起过程中的作用,进一步讨论甲状腺素对人类勃起功能的影响。方法:将50只3月龄雄性Wistar大鼠随机均分为甲亢组、甲亢治疗组、甲减组、甲减治疗组及正常对照组。用紫外分光光度计分别测定阴茎海绵体内NOS及CO的含量。结果:无论甲状腺素增多及减少都会使大鼠阴茎海绵体NOS含量降低(P<0.01),并且甲减组阴茎海绵体内NOS活性低于甲亢组(P<0.01)。无论甲状腺素增多还是减少都会使大鼠阴茎海绵体内CO含量降低(P<0.01),并且甲亢组阴茎海绵体内CO活性低于甲减组(P<0.01)。在对甲减组及甲亢组进行治疗后其CO及NOS的含量得到提高,与正常对照组无显著差异(P>0.05)。结论:甲状腺功能紊乱情况下阴茎海绵体中NOS和CO的浓度均减低;甲状腺功能紊乱被及时纠正后阴茎海绵体中CO及NOS的含量可恢复到正常水平。在相同条件下甲状腺功能低下对性功能的损害强于甲状腺功能亢进对勃起功能的损害。 |
| 关 键 词： | 甲状腺功能亢进 甲状腺功能减退 一氧化氮合酶 一氧化碳 一氧化氮 阴茎海绵体 |
Effect of Thyroid Hormone on the Contents of NOS and CO in the Penile Corpus Cavernosum of Rats |
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| HU Cun-li,WU Ya-dong,LIU Hong-tao,QIN Wen-bo,WANG Guo-zheng. Effect of Thyroid Hormone on the Contents of NOS and CO in the Penile Corpus Cavernosum of Rats[J]. National journal of andrology, 2009, 15(1): 37-40 | |
| Authors: | HU Cun-li WU Ya-dong LIU Hong-tao QIN Wen-bo WANG Guo-zheng |
| Affiliation: | HU Cun-li1,WU Ya-dong2,LIU Hong-tao3,QIN Wen-bo3,WANG Guo-zheng11. Department of Urology,2. Department of Obstetrics , Gynecology,The First Hospital Affiliated to Jiamusi University,Jiamusi,Heilongjiang 154002,China,3. Department of Urology,Daqing Oil Field General Hospital,Daqing,Heilongjiang 163001 |
| Abstract: | Objective:To determine the contents of NOS and endogenous CO in the penile corpus cavernosum of Wistar rat models of hyperthyroid and hypothyroid, to detect the effects of thyroid hormone and endogenous CO on rat penile erection, and to further investigate the influence of thyroid hormone on human penile erection. Methods: Fifty 3-month-old male Wistar rats were randomly and equally divided into 5 groups: a hyperthyroid, a hyperthyroid treatment, a hypothyroid, a hypothyroid treatment and a control group. T... |
| Keywords: | hyperthyroid hypothyroid NOS CO NO corpus cavernosum |
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