| 胆固醇负荷对家兔血浆低密度脂蛋白分子颗粒及脑动脉硬化的影响 |
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| 引用本文： | 何志义,吕昌龙,傅国,李绍英. 胆固醇负荷对家兔血浆低密度脂蛋白分子颗粒及脑动脉硬化的影响[J]. 中国医科大学学报, 1998, 0(5) |
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| 作者姓名： | 何志义 吕昌龙 傅国 李绍英 |
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| 作者单位： | Department of Neurology，The First Clinical College，China Medical University，Shenyang，110001 |
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| 摘 要： | 目的：阐明低密度脂蛋白（ＬＤＬ）分子颗粒与脑动脉粥样硬化之间的内在关系。方法：以胆固醇负荷家兔为动物模型，从血浆ＬＤＬ的脂质生化学和超微形态学的角度对其进行动态观察。结果：随着胆固醇负荷时间的增加，血浆ＬＤＬ中脂质过氧化物（ＬＰＯ）和载脂蛋白Ｂ（ＡｐｏＢ）的含量逐渐增加，血浆ＬＤＬ分子颗粒也明显增大。结论：血浆ＬＤＬ分子颗粒的增大可能是引起脑动脉粥样硬化形成的原因之一。因此，膳食结构的改变可以预防和阻止脑动脉粥样硬化的形成。
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| 关 键 词： | 胆固醇负荷；低密度脂蛋白；动脉粥样硬化 |
The Effects of Cholesterol Feeding on Molecular Size of Low Density Lipoprotein and Cerebral Atherosclerosis in Rabbits |
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| He Zhiyi,L Canglong,Fu Guo,et al. The Effects of Cholesterol Feeding on Molecular Size of Low Density Lipoprotein and Cerebral Atherosclerosis in Rabbits[J]. Journal of China Medical University, 1998, 0(5) |
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| Authors: | He Zhiyi L Canglong Fu Guo et al |
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| Abstract: | Objective:This paper was to investigate the association of low bensity lipoprotein(LDL) with cerebral atherosclerosis. Methods:We observed the biochemical and ultrastructural changes of LDL in plasma from rabbits after they were fed with cholesterol. Results: The levels of lipid peroxide(LPO) and apolipoprotein B(ApoB) in plasma increased significantly, and molecular size of LDL also enlarged in the plasma. Conclusions: The change of molecular size in LDL may be one of the causes for cerebral atherosclerosis that can be prevented when the constituents in food are changed. |
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| Keywords: | cholesterol feeding low density lipoprotein cerebral atherosclerosis |
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