消遥散合二陈汤加减治疗乳腺增生病临床观察

用消遥散合二陈汤加减治疗乳腺增生病51例,总有效率96.1%。每例患者在用药前及用药后的卵泡期,分别进行唾液雌二醇(E_2)、孕酮(P)、睾酮(T)及血清泌乳素(PRL)水平测定和乳腺钼靶 X 线摄影检查对照。用药后 E_2及 PRL 浓度下降,与用药前比较差异有非常显著性意义(P<0.001及 P<0.005),P 差异有显著意义(P<0.05),T无明湿改变。乳腺钼靶 X 线摄影检查,增生腺体有部分吸收者21例。说明该方药有调节内分泌作用。可能通过抑制 PRL 分泌,减少其对促卵泡成熟激素的拮抗作用恢复卵巢功能,并有调整垂体—卵巢轴分泌使之规律的效用。

Observation on Treatment of Breast Proliferation Bisease with Modified

Dept.of Surgery TCM,The First Affiliated Hospital of Shanxi Medical College,Taiyuan(030001) The authors report the 3 months'treatment of 51 cases of breast proliferation disease with modified Xiao Yao San and Er Chen decoction,an effective rate being 96.1%.In each patient before and after treatment,saliva estradiol(SE_2),saliva progesterone(SP),saliva testosterone(ST)and Plasma prolactin(PRL)concentrations were monitored and breast molybdenum-target X-ray films were taken.The results showed that after treatment,SE_2 concentrations declined very significantly (P<0.001);SP concentrations declined significantly(P<0.05);PRL concentrations declined very significantly(P<0.005),but ST concentrations did not change significantly.Breast molybdenum- target X-ray films showed absorption of proliferation masses in 21 cases.These indicated that the medicine could regulate endocrine system,perhaps through suppressing secretion of PRL,decreasing prolactin antagonist action to follicular stimulating hormone so as to restore follicle function,and could regulate pituitary-follicle axis and make the axis normal.