| 7—溴化乙氧苯四氢巴马汀对豚鼠乳头肌及心房的作用 |
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| 引用本文： | 杨宝峰,姚伟星,夏国瑾,江明性. 7—溴化乙氧苯四氢巴马汀对豚鼠乳头肌及心房的作用[J]. 中国药理学通报, 1990, 0(5) |
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| 作者姓名： | 杨宝峰 姚伟星 夏国瑾 江明性 |
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| 作者单位： | [1]哈尔滨医科大学药理教研室 [2]同济医科大学药理教研室 [3]哈尔滨 |
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| 摘 要： | 7—溴化乙氧苯四氢巴马汀(EBP)能降低豚鼠乳头状肌自律性及右房自律性;显著延长豚鼠乳头肌功能不应期,并能增加收缩性,对兴奋性无影响。EBP 10μmol/L对左房收缩性无影响,300μmol/L使左房收缩力明显增加。延长不应期,降低自律性与EBP抗心律失常作用有关。
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| 关 键 词： | 7-溴 化 乙氧苯四氢巴马汀 自律性 不应期 豚鼠乳头状肌 |
EFFECTS OF 7-BROMETHYOXYBENZENTETRAHYDROPALMATINE ON GUINEA PIG PAPILLARY MUSCLES AND ATRIUM |
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| Yang Baofeng. EFFECTS OF 7-BROMETHYOXYBENZENTETRAHYDROPALMATINE ON GUINEA PIG PAPILLARY MUSCLES AND ATRIUM[J]. Chinese Pharmacological Bulletin, 1990, 0(5) |
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| Authors: | Yang Baofeng |
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| Abstract: | 7-Bromethyoxybenzentetrahydropalmatine ( EBP) possessed antiarr-hythmic effect in several animals models.The authors studied the direct influence of EBP on the automaticity, refractory period, excitability and the contractility of isolated papillary muscle and atrium of guinea pig.EBP was found to decrease the automaticity and prolong the functional refractory period and increase the contractility of guinea pig papillary muscle, but it exerted no influence on its excitability.The decrease in automoticity and prolongation of refractory period was thought to be ascribed to its antiarrhythmic action. |
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| Keywords: | Bromethyoxybenzentetrahydropalmatine Automaticity: Refractory period Guinea pig papillary muscle |
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