组织多普勒成像技术评价冠心病心肌梗死后左室整体功能

 目的 应用超声心动图对冠心病心肌梗死患者进行检测,寻找与左室功能相关性良好的指标以利于临床评估.方法 对经临床及冠状动脉造影确诊的心肌梗死(1～6个月)患者68例行多普勒超声心动图检查.根据其二尖瓣口血流频谱形态将患者分为3组:左室松弛性减低组、假性正常化组、限制性充盈组；又根据心脏射血分数(ejection fraction,EF)值将患者分为两组:EF≥50％,EF＜ 50％,将各多普勒超声心动图参数在各组对比分析.结果 随着心脏舒张功能障碍的进展,运用组织多普勒技术(TDI)测得的二尖瓣环舒张早期峰值速度(Ea)及其与舒张晚期峰值速度(Aa)的比值Ea/Aa降低(P＜0.01),其差别尤其表现在对照组与左室松弛性减低组及其与假性正常化组之间(P＜0.01).在正常对照组、冠心病心肌梗死EF正常组及冠心病心肌梗死EF减低组TDI测得的二尖瓣环收缩期峰值速度Sa、Ea及Ea/Aa比值呈逐渐降低趋势(P＜0.01).而且Spearman相关分析表明:Ea值及Ea/Aa比值与左室舒张功能障碍分级相关性良好,Sa与EF值相关性良好.结论 冠心病心肌梗死患者出现左室舒张功能障碍常先于左室收缩功能障碍,TDI测得的Ea及Ea/Aa比值可用于鉴别左室舒张功能的假性正常化；TD1测得的Sa可作为评估冠心病心肌梗死患者左室收缩功能的重要参数.

Assessment of left ventricular function using tissue Doppler imaging in patients with myocardial infarction

Objective To examine patients with myocardial infarction to obtain variables closely correlated with the left ventricular function.Methods Doppler echocardiography was performed in 68 patients with myocardial infarction in various stages of diastolic and systolic dysfunction and 52 normal controls.The patients were divided into three groups according to their mitral flow spectrum, (1)delayed left ventricular relaxation,(2)pseudo-normal left ventricular filling,(3)restrictive left ventricular filling.They we...