| 恩替卡韦治疗乙肝病毒重型肝炎肝衰竭的随机对照试验的Meta分析 |
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| 引用本文： | 卢向鹏,罗光汉,陈茂伟,甄秀梅. 恩替卡韦治疗乙肝病毒重型肝炎肝衰竭的随机对照试验的Meta分析[J]. 武警医学, 2011, 22(9): 779-781,785 |
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| 作者姓名： | 卢向鹏 罗光汉 陈茂伟 甄秀梅 |
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| 作者单位： | 武警广西总队医院传染科,南宁,530003;广西医科大学第一附属医院感染科,南宁,530000 |
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| 摘 要： | 目的 系统评价恩替卡韦( entecavir,ETV)治疗乙型肝炎病毒(HBV)相关性肝衰竭(重型肝炎)的效果.方法 检索2005 - 01至2010 - 03在PubMed、Ovid、Spring Link、Biosis Previews、Academic Research Premier (ASP)、Cochrane和CNKI、VIP、CBM收录的有关内科常规治疗基础上加用ETV抗病毒对HBV相关性肝衰竭/重型肝炎患者病死率影响的随机对照试验(RCT),2名研究者独立采用Jadad评分对全部纳入文献进行质量评价,异质性分析使用x2检验,以比值比(OR)为效应量进行Meta分析.结果 共纳入5篇RCT,病死率合并效应量(OR)为0.25,95％可信区间(95％ CI)为0.15 ～0.41,P＜0.01.结论 与内科常规治疗相比,加用ETV抗病毒可以显著降低HBV相关性肝衰竭(重型肝炎)患者的病死率.
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| 关 键 词： | 恩替卡韦 肝衰竭:病死率 Meta分析 |
Effect of entecavir on reducing mortality of HBV - related liver failure: a meta - analysis |
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| LU Xiangpeng,LUO Guanghan,CHEN Maowei,ZHEN Xiumei. Effect of entecavir on reducing mortality of HBV - related liver failure: a meta - analysis[J]. Medical Journal of the Chinese People's Armed Police Forces, 2011, 22(9): 779-781,785 |
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| Authors: | LU Xiangpeng LUO Guanghan CHEN Maowei ZHEN Xiumei |
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| Affiliation: | LU Xiangpeng~1,LUO Guanghan~2,CHEN Maowei~2,and ZHEN Xiumei~2.1.Department of Infectious Disease,Guangxi Zhuang Autonomous Region Crops Hospital,Chinese People's Armed Police Forces,Nanning 530003,China,2.Department of Infectious Disease,First Affiliated Hospital,Guanxi Medical University,Nanning 530000 |
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| Abstract: | Objective To evaluate the effect of entecavir on reducing mortality of HBV-related liver failure.Methods Pubmed,Ovid,Spring Link,Biosis Previews,Academic Research Premier,the Cochrane library and CBM,VIP,CNKI were searched from January 2005 to March 2010.Randomized controlled trials comparing entecavir with routine medical treatment for liver failure were eligible for inclusion.Relevant literature that dealt with mortality was chosen.Two investigators independently assessed the quality and extracted the dat... |
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| Keywords: | entecavir liver failure mortality meta analysis |
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