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Rotator cuff changes in a full thickness tear rat model: verification of the optimal time interval until reconstruction for comparison to the healing process of chronic lesions in humans
Authors:Buchmann Stefan  Walz Lars  Sandmann Gunther H  Hoppe Henriette  Beitzel Knut  Wexel Gabriele  Battmann Achim  Vogt Stephan  Hinterwimmer Stefan  Imhoff Andreas B
Affiliation:(1) Department of Orthopaedic Sports Medicine, Klinikum rechts der Isar, Technical University of Munich, Connollystr. 32, 80805 Munich, Germany;(2) Clinical Trial Unit, University Hospital Basel, Schanzenstr. 55, 4031 Basel, Switzerland;(3) Department of Traumatology, Klinikum rechts der Isar, Technical University of Munich, Ismaningerstr. 22, 81675 Munich, Germany;(4) Department of Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich, Ismaningerstr. 22, 81675 Munich, Germany;(5) Institute for Pathology and Cytodiagnostics, Urselerstr. 33, 61348 Bad Homburg v.d.H, Germany
Abstract:

Background  

The aim of the study was to develop a standardized rat model for chronic rotator cuff tears. Therefore, a time point of degenerative changes that shows comparable histological changes to the chronic tendon tears in humans had to be determined. The rat shoulder has already been described as a standardized model for investigation of the healing behavior in acute supraspinatus lesions. Little data exist about the possibility of generating a chronic rotator cuff lesion.
Keywords:
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