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A 5-mm femoral defect in female but not in male rats leads to a reproducible atrophic non-union |
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| Authors: | Manav Mehta Hanna Schell Carolin Schwarz Anja Peters Katharina Schmidt-Bleek Agnes Ellinghaus Hermann J. Bail Georg N. Duda Jasmin Lienau |
| Affiliation: | 1.Julius Wolff Institute and Center for Musculoskeletal Surgery,Charité?-?Universit?tsmedizin Berlin,Berlin,Germany;2.Berlin-Brandenburg Center for Regenerative Therapies,Charité?-?Universit?tsmedizin Berlin,Berlin,Germany;3.Klinik für Unfall- und Orthop?dische Chirurgie, Klinikum Nürnberg,Nuremberg,Germany |
| Abstract: | IntroductionThe objectives of this study were to (1) establish a reproducible atrophic non-union model in rats by creation of a segmental femoral bone defect that allows, (2) in-depth characterization of impaired healing, and (3) contrast its healing patterns to the normal course. Hypothesis was that a 5-mm bone defect in male rats would deviate from uneventful healing patterns and result in an atrophic non-union. |
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