An Autopsied Case of Acute Hemorrhagic Leukoencephalitis |
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Authors: | Yoshio Mitsuyama M D Shoichi Fujimoto M D Tadashi Kohno M D |
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Institution: | Department of Psychiatry, Miyazaki Medical College, Miyazaki;*Department of the First Internal Medicine, Miyazaki Medical College, Miyazaki;**Department of Pathology, Miyazaki Medical College, Miyazaki |
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Abstract: | Abstract: This is a clinico-pathological study of one case of acute hemorrhagic leukoencephalitis occurring in a patient with lung cancer. The main changes observed by light microscopywere in the white matter. All of these changes were the result of hemorrhage and demyelination around the venous vessels. Glial mesenchymal reactions were minimal. In view of these findings, this case supports the hypothesis that immune mechanisms play a role in the pathogenesis of neuropsychiatric symptoms during malignant illnesses. Here we will discuss the problem of differential diagnoses of acute hemorrhagic leukoencephalitis and its close morphologic similarities to perivenous encephalitis. Acute hemorrhagic leukoencephalitis and perivenous encephalitis may be a single entity of a demyelinating disease. |
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Keywords: | lung cancer perivenous hemorrhage and demyelination immune mechanism |
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