| 青蒿素固体脂质纳米粒冻干剂的体外释药性质研究 |
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| 引用本文： | 朱九群,傅 川,何 林,等. 青蒿素固体脂质纳米粒冻干剂的体外释药性质研究[J]. 实用医院临床杂志, 2014, 0(2): 18-20 |
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| 作者姓名： | 朱九群 傅 川 何 林 等 |
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| 作者单位： | [1]四川省医学科学院·四川省人民医院药学部,四川成都610072 [2]重庆医科大学附属永川医院药学部,重庆永川402160 [3]四川省邛崃市医疗中心医院药学部,四川邛崃611350 |
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| 基金项目： | 四川省卫生厅科研基金资助项目（编号：130547） |
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| 摘 要： | 目的探讨青蒿素固体脂质纳米粒（ART—SLN）的体外释药性质。方法采用动态透析法测定释药介质中的青蒿素累计释放含量，并用不同的数学模型模拟释放行为。结果青蒿素在乙醇溶液中的溶出曲线采用Weibull方程拟合效果最佳。结论ART—SLN具一定缓释作用，达到预期目标。
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| 关 键 词： | 青蒿素 固体脂质纳米粒 体外释药 |
The characteristics of drug release in vitro of a lyophilized agent of artemisinin solid lipid nanoparticles |
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| ZHU Jiu-qun,FU Chuan,HE Lin,ZENG Ming-hui. The characteristics of drug release in vitro of a lyophilized agent of artemisinin solid lipid nanoparticles[J]. Practical Journal of Clinical Medicine, 2014, 0(2): 18-20 |
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| Authors: | ZHU Jiu-qun FU Chuan HE Lin ZENG Ming-hui |
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| Affiliation: | 1. Department of Pharmacy, Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People＇s Hospital,Chengdu 610072,China ;2. Department of Pharmacy, Yongchuan Hospital Affiliated to Chongqing Medical University, Yongchuan 402160, China ;3. Department of Pharmacy ,Medical Central Hospital of Qionglai City ,Sichuan Province, Qionglai 611350, China) |
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| Abstract: | Objective To study the characteristics of drug release in vitro of a lyophilized agent of artemisinin-loaded solid lipid Nan particle（ART-SLN）. Methods Accumulated contents of artemisinin in the release medium were determined by using a dynamic dialysis method, and the release behavior was simulated with different mathematical models. Results The Weibull equation was the best to simulate the release characteristics of artemisinin in ethanol elution curves. Conclusion The ART-SLN has a certain slow release function that is able to achieve the desired objectives. |
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| Keywords: | Artemisinin Solid lipid nanoparticle Release in vitro |
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