| 黄连解毒汤对动脉粥样硬化大鼠血SICAM-1和SVCAM-1的影响 |
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| 引用本文： | 李国强,黄萍,程穗茗,罗承锋,刘世明,郭重仪,操红缨. 黄连解毒汤对动脉粥样硬化大鼠血SICAM-1和SVCAM-1的影响[J]. 广东医学, 2009, 30(11) |
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| 作者姓名： | 李国强 黄萍 程穗茗 罗承锋 刘世明 郭重仪 操红缨 |
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| 作者单位： | 广州医学院第二附属医院心内科、广州心血管疾病研究所,广州,510260;广州中医药大学中医学院,广州,510405 |
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| 基金项目： | 广东省中医药管理局立项项目 |
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| 摘 要： | 目的 探讨黄连解毒汤对动脉粥样硬化大鼠血清中细胞间黏附分子-1(ICAM-1)和血管细胞黏附分子-1(VCAM-1)水平的影响及其作用机制.方法 雄性SD大鼠,随机分成正常对照组、模型对照组、黄连解毒汤低中高3个剂量组及阿托伐他汀组,每组10只.除正常对照组喂普通饲料外,其余喂以高脂饲料,同时定期灌服维生素D3(60万U/次,第2,4,6周)造模8周,从第6周开始每天灌胃给药1次,黄连解毒汤低剂量组2.7 g/kg,中剂量组5.3 g/kg,高剂量组10.6 g/ks,阿托伐他汀钙片组1.8mg/kg,正常对照组灌服等量蒸馏水,连续4周.结果 黄连解毒汤中剂量组,高剂量组及阿托伐他汀组均与模型对照组的ICAM-1,VCAM-1表达均比模型对照组低(P<0.05～0.01).结论 黄连解毒汤对动脉粥样硬化起到一定干预作用,其机制可能与抑制炎症反应有关.
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| 关 键 词： | 动脉粥样硬化 动物实验 黄连解毒汤 ICAM-1 VCAM-1 |
The effects of huang lian jie du decoction on immune-inflammatory cytokine sICAM-1 and sVCAM -1 in rats with atherosclerosis |
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| LI Guo-qiang,HUANG Ping,CHENG Sui-ming,LUO Cheng-feng,LIU Shi-ruing,GUO Zhong-yi,CAO Hong-ying. The effects of huang lian jie du decoction on immune-inflammatory cytokine sICAM-1 and sVCAM -1 in rats with atherosclerosis[J]. Guangdong Medical Journal, 2009, 30(11) |
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| Authors: | LI Guo-qiang HUANG Ping CHENG Sui-ming LUO Cheng-feng LIU Shi-ruing GUO Zhong-yi CAO Hong-ying |
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| Affiliation: | LI Guo-qiang,HUANG Ping,CHENG Sui-ming,LUO Cheng-feng,LIU Shi-ming,GUO Zhong-yi,CAO Hong-ying. Department of Cardiology,the second Affiliated Hospital of Guangzhou Medial College,Guangzhou Institute of Cardiovascular disease,Guangzhou 510260,China |
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| Abstract: | Objective To study the effect of huang lian jie du decoction on immune-inflammatory cytokine sICAM -1 and sVCAM -1 in rat serum and its molecular mechanism. Methods Male rats were divided into 6 groups,5 groups were fed with cholesterol diet for 10 weeks and the other group was fed with normal diet. At the sixth week 3 groups were treated with low dose,moderate dose and the high dose of huang lian jie du decoction,one group with atorvastatin for 4 weeks (except the nomal group ) Levels of sICAM -1 and sVCAM... |
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| Keywords: | ICAM-1 VCAM-1 |
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