1997年中国部分省狂犬病疫情回升与疫苗质量下降关系

本文报导了１９９７年中国部分省区狂犬病疫情回升情况，全回升率３９.６ ％（ ２２２／１５９） ，其中以江西 、江苏和广西三省区较高， 分别为２８５.７ ％ （２７／７） 、１０９.１ ％ （２３／ １１） 、１０８.３ ％ （ ５０／２４） 。其原 因近年 疫苗生产 受到市 场经济冲 击，疫 苗质 量不 稳定。 如全 程 接种 后 抗体 逐年 下 降，其阳性率由 １９９４ 年９１ ３ ％ （５４３／５９ ５） 下 降至 １９９８ 年 ６８.０ ％（２ ９５／４３２） 下 降 了２３.０ ％ 。 在同 一疫苗来源时 ，接种２针与３针，抗 体阳转率１９９６ 年 比１９９４ 年 分别下降了１８.０ ％ 与 ４６.０ ％，具有显著性意义，χ２ ＝５．５５， Ｐ＜ ００５ 。也出 现了２例 无效病 例。国家１９９６年抽检 结果也证实，作者对１９９８ 年后全国疫情作了预测。

The Relationship between the Reincreasing Rate of Rabies and the Quality of Vaccine in Some Provinces in China 1997

The morbidity of rabies was increased again in some provinces of China 1997. The re-increasing rate was 39.6%(222/159) but it was very apparent in Jiangxi (285.7%, 27/7), Jiangsu (109.1%,23/11) and Guangxi (108.3%, 50/24). The cause may be related to the quality of vaccine. For instance, the antibody titer of post-vaccination was decreased yearly. The positive converse rate was decreased from 91.3%(543/595) in 1994 to 68% (295/432) in 1998. Even using the vaccine made by the same factory, the positive converse rates after 2nd and 3rd vaccination in 1996 were decreased by 18% and 46% in comparison with 1994 (p<0.05). Furthermore two cases without any effect were reported. National control center showed a similar tendency. The expected morbidity of rabies in 1998 in China was forecased.