Clinical manifestations and treatment of newly diagnosed acute lymphoblastic leukemia in adults |
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Authors: | Heather Landau MD Nicole Lamanna MD |
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Institution: | (1) Leukemia Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021 New York, NY, USA |
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Abstract: | Adult acute lymphoblastic leukemia (ALL) is a heterogeneous disease with distinct biologic and prognostic subgroups. The treatment
of adults with ALL has evolved largely from the therapy developed for childhood ALL and, despite differences across regimens,
can be broadly classified as including induction, consolidation, maintenance, and central nervous system prophylaxis. Although
there has been marked improvement in the outcomes for pediatric patients with ALL, the same success has not yet been realized
for adult patients. Some of this difference can be attributed to a greater incidence of unfavorable cytogenetic subtypes in
adults than in children. In addition, the ability to tolerate intensive regimens likely plays a role. This article reviews
the classification, prognostic features, current treatment programs, and new advances as applied to adult patients with newly
diagnosed ALL. |
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