重组人红细胞生成素对尿毒症血液透析患者生活质量的影响

目的探讨大剂量重组人红细胞生成素(益比奥,EPO)对尿毒症维持血液透析(血透)患者生活质量的影响。方法选择规律血透1个月以上尿毒症患者随机分为2组。观察组系统给予大剂量益比奥1万IU每周1次皮下注射。对照组未系统给予促红素治疗。随访6个月,观察血红蛋白(Hb)、血清白蛋白(ALB)、血清肌酐(Cr)、血清尿素氮(BUN)、超声心动图及生存质量(WHO-QOL)等指标。结果6个月后观察组患者Hb、ALB均显著高于对照组(P<0.05);左室肥大(LVH)、左室心肌质量指数(LVMI)显著低于B组(P<0.05);Hb与ALB呈正相关;观察组患者的WHO-QOL显著高于对照组。BUN、Cr两组间无显著差异。结论益比奥应用提高了尿毒症患者的Hb,改善了患者的营养状况,减少了心血管系统并发症的发生,提高了患者的生活质量。

The effects of erythropoietin on quality of life in uremic patients in maintenance hemodialysis

Aim To investigation the effect of large dosage of EPO on quality of life in uremic patients in maintenance hemodialysis.Methods 46 patients of maintenance hemodialysis were choiced, Who were divided into two groups randomly. The treatment group was given large dose EPO 10000u once weekly;The control group were given EPO no regulation. In flowing observation Hb,ALB,Cr,BUN,WHO QOL were measured before and after 6 months therapy.Results Hb,ALB of the treatment group are higher obviously than that of the control group after 6 months therapy. There are a positive correlation between Hb and ALB. The scores of WHO QOL are higher in treatment group than that in control group. There is no differential in BUN and Cr between treatment group and controls.Conclusion EPO can increase Hb ,enhance the nutrient status, decrease the complication of cardiovascular disease and improve the quality of life in the uremic patients in maintenance hemodialysis.