中西医结合治疗对黏连性肠梗阻血清炎性因子水平的影响

目的探讨中西医结合治疗粘连性肠梗阻的临床疗效。方法本院收治的粘连性肠梗阻患者54例随机分为中西医结合组和对照组，每组27例。对照组仅给予西医常规治疗，中西医结合组在对照组治疗基础上给予中医治疗。观察2组临床疗效、腹痛消失时间、排气时间、排便时间、气液平面消失时间，放射免疫法检测血清中肿瘤坏死因子-a（TNF—α）、白细胞介素-6（IL-6）水平。结果中西医结合组总有效率高于对照组，但2组比较无显著差异。中西医结合组腹痛消失时间、排气时间、排便时间、气液平面消失时间均明显短于对照组。2组治疗第3天、第7天血清TNF-α、IL-6水平均较治疗前明显降低；治疗第7天血清TNF-α、IL-6水平明显低于治疗第3天。中西医结合组治疗第3天、第7天血清TNF-α、IL-6水平明显低于对照组。结论中西医结合治疗粘连性肠梗阻疗效优于单纯西医常规治疗，能降低粘连性肠梗阻患者血中TNF-α、IL-6水平，具有免疫调节、减轻炎症反应作用，从而提高临床疗效。

Influence of integrated treatment of Chinese medicine and western medicine on serum inflammatory cytokines level of adhesive intestinal obstruction

Objective To explore the clinical effect of integrated treatment of Chinese medicine and western medicine on serum inflammatory cytokines level of adhesive intestinal obstruction. Methods 54 patients with adhesive intestinal obstruction were randomly divided into control group and integrated Chinese and western medicine group with equivalent patients. The patients in the control group were given conventional treatment of western medicine while integrated Chinese and western medicine group were additionally conducted Chinese medical treatment based on the treatment of control group. During the research, clinical effects, disappearance time of abdominal pain, exhausting time, defecation time and air fluid level time in both groups were observed. Mean- while, the levels of tumor necrosis factor-a （TNF-a） in serum and interleukin-6 （IL-6） were detect- ed by radioimmunoassay. Results The total efficiency in integrated Chinese and western medicine group was higher than that in control group. However, the result revealed that there was no signifi- cant differences between the two groups. Disappearance time of abdominal pain, exhausting time, defecation time and air fluid level time in integrated Chinese and western medicine group was shorter than that of the control group. Levels of TNF-ain serum and IL-6 decreased evidently in both groups on the third and the seventh day, and they were lower on the seventh day than on the third day. Compared with the levels of TNF-ain serum and IL-6 in the control group, they were much lower in integrated Chinese and western medicine group on the third day and the seventh day after treatment. Conclusion The clinical effect of integrated Chinese and western medicine therapy is superior to western medicine therapy in treating adhesive intestinal obstruction. It reduces TNF-a and IL-6 levels, regulates immunity, alleviates inflammation and improves the clinical effect.