首页 | 本学科首页   官方微博 | 高级检索  
     


Phenprocoumon metabolites in human plasma; characterization by HPLC and GC-MS
Authors:de Vries  J. X.  Zimmermann  R.  Harenberg  J.
Affiliation:(1) Department of Clinical Pharmacology, University of Heidelberg, Heidelberg, Germany;(2) Department of Internal Medicine I, Medical Clinic, University of Heidelberg, Heidelberg, Germany
Abstract:Summary Pooled plasma from patients receiving phenprocoumon anticoagulant therapy was extracted and the following substances were characterized: phenprocoumon, and its 7-hydroxy,4prime-hydroxy and 6-hydroxy derivatives; they were identified by HPLC and after methylation by quartz capillary GC-MS using the electron impact and selective ion monitoring modes. This is the first occasion when phenprocoumon metabolites have been identified in plasma; they were unconjugated and in much lower concentrations (43.2 and 2 ng/ml for the 7,4prime and 6-hydroxy derivatives, respectively) than the original compound (2000 ng/ml).
Keywords:phenprocoumon  oral anticoagulant  metabolites in plasma  patients
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号