Phenprocoumon metabolites in human plasma; characterization by HPLC and GC-MS |
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Authors: | de Vries J. X. Zimmermann R. Harenberg J. |
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Affiliation: | (1) Department of Clinical Pharmacology, University of Heidelberg, Heidelberg, Germany;(2) Department of Internal Medicine I, Medical Clinic, University of Heidelberg, Heidelberg, Germany |
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Abstract: | Summary Pooled plasma from patients receiving phenprocoumon anticoagulant therapy was extracted and the following substances were characterized: phenprocoumon, and its 7-hydroxy,4-hydroxy and 6-hydroxy derivatives; they were identified by HPLC and after methylation by quartz capillary GC-MS using the electron impact and selective ion monitoring modes. This is the first occasion when phenprocoumon metabolites have been identified in plasma; they were unconjugated and in much lower concentrations (43.2 and 2 ng/ml for the 7,4 and 6-hydroxy derivatives, respectively) than the original compound (2000 ng/ml). |
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Keywords: | phenprocoumon oral anticoagulant metabolites in plasma patients |
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