| 大鼠创伤修复中血小板源生长因子免疫组织化学的变化 |
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| 引用本文： | 周茂华,邢同义,姚飞. 大鼠创伤修复中血小板源生长因子免疫组织化学的变化[J]. 中国组织工程研究与临床康复, 2002, 6(22): 3369 |
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| 作者姓名： | 周茂华 邢同义 姚飞 |
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| 作者单位： | 1. 武装警察部队医学院附属医院,天津,300162
2. 武装警察部队医学院,天津,300162 |
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| 基金项目： | 武警总部科研资助项目(WK97108) |
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| 摘 要： | 目的探讨创伤模型大鼠皮肤创面愈合过程中,血小板源生长因子(PDGF)表达的动态变化。方法采用免疫组织化学研究伤后3,6,9,12dPDGF表达的变化。结果创伤愈合PDGF表达在伤后6d呈强阳性,图像象分析,伤后6d与3d比较PDGF表达差异有显著性意义(P<0.01)。结论PDGF的表达变化和创面修复有密切关系,PDGF在创面愈合过程中有着规律性的变化并发挥十分重要的调控作用。
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| 关 键 词： | 创伤修复 血小板源生长因子 调控作用 |
| 文章编号： | 1671-5926(2002)22-3369-02 |
| 修稿时间： | 2002-09-27 |
The change of expression of PDGF during the wound healing in rat skin |
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| ZHOU Mao-hua,XING Tong-yi,YAO fei,et al.. The change of expression of PDGF during the wound healing in rat skin[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2002, 6(22): 3369 |
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| Authors: | ZHOU Mao-hua XING Tong-yi YAO fei et al. |
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| Affiliation: | ZHOU Mao-hua,XING Tong-yi,YAO fei,et al.Research Center of Burn and Plastic Surgery,Affiliated Hospital of Medical Colle ge of Chinese People' s Armed Police Forces,Tianjin 300162,China |
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| Abstract: | Objective To study the expression and change of regularity of endogenous Platelet derived growth factor(PDGF)in the process of wound healing in rat skin.Methods The wound models were made in the back skin of rat,then the specimens in the wound site were harvested after 3,6,9,12days.At th e same time,normal skin was harveste d to used as control.Immunohistochemistry was employed to detect the expression of PDGF.Results Endogenous PDGF were detects in fibr oblasts in wound site during 3to 12days after wound repair,high expression were detected in 6th day p ost-injury.Quantitative analysis of the level of PDGF expression of 6days was much higher then that of the3days(P<0.01).Conclusions PDGF is definitive and important in t he process of wound healing. |
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| Keywords: | wound repair PDGF regulation |
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