| Abstract: | Electrical stimulation of a suspension of rat brain synaptosomes leads to significant Ca++-dependent liberation of endogenous noradrenalin and to a Ca++-dependent increase in its concentration in the synaptosomes themselves. Cyclic nucleotide phosphodiesterase activity is lowered significantly under these same conditions. No disturbance of synaptosomal ultrastructure is found during stimulation. An increase in the number of electron-dense synaptosomes is observed.Laboratory of General Pathology of the Nervous System, Laboratory of Experimental Pathomorphology and Ultrastructural Characteristics of Pathological Processes, Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. M. Chernukh.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 89, No. 2, pp. 143–145, February, 1980. |
