| 吸烟对氧自由基和纤溶系统的影响 |
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| 引用本文： | 王勤,周宏研,孙明,贾真. 吸烟对氧自由基和纤溶系统的影响[J]. 中南大学学报(医学版), 1997, 0(2) |
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| 作者姓名： | 王勤 周宏研 孙明 贾真 |
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| 作者单位： | 附属湘雅医院心血管内科，广州市红十字会医院 |
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| 摘 要： | 动态观察２０名健康男性急性吸烟前后超氧化物歧化酶（ＳＯＤ），丙二醛（ＭＤＡ），组织型纤溶酶原激活剂（ｔ－ＰＡ）和纤溶酶原激活剂抑制物（ＰＡＩ－１）活性的改变。结果表明：受试者急性吸烟后ＳＯＤ增加（Ｐ＜０．０５），ＭＤＡ减少（Ｐ＜０．０５）；纤溶系统有短暂激活。吸烟者ｔ－ＰＡ的释放较不吸烟者减少（Ｐ＜０．０５）；ｔ－ＰＡ的释放与ＳＯＤ呈正相关，与ＭＤＡ呈负相关。
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| 关 键 词： | 吸烟；超氧化物歧化酶；丙二醛；组织型纤溶酶原；激活剂；纤溶酶原激活剂；抑制物 |
EFFECTS OF SMOKING ON OXYGEN FREE RADICALS AND FIBRINOLYTIC SYSTEM |
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| Wang Qin Zhou Hongyan Sun Ming Jia Zhen. EFFECTS OF SMOKING ON OXYGEN FREE RADICALS AND FIBRINOLYTIC SYSTEM[J]. Journal of Central South University. Medical sciences, 1997, 0(2) |
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| Authors: | Wang Qin Zhou Hongyan Sun Ming Jia Zhen |
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| Abstract: | The effects of smoking on SOD, MDA, t PA, PAI 1 were studied in 20 healthy men (10 smokers and 10 nonsmokers). Results: SOD decreased and MDA increased significantly in smokers. After acute smoking, SOD decreased and MDA increased significantly in all the subjects. t PA and PAI 1 activities were increased immediately after acute smoking. There was a significant positive relationship between increased t PA and SOD, whereas a significant negative relationship exists between increased t PA and MDA. Conclusion: Smoking increases oxygen free radicals. The release of t PA is decreased in smokers, that might be resulted from the increases of oxygen free radicals. |
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| Keywords: | Smoking superoxide Dismutase malondialdehyde oxygen free radicals Tissue type plasminogen activator plasminogen activator in inhibitor fibrinolytic system |
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