人胚胎期小肠六种肽能神经发生的研究

采用免疫组织化学ＰＡＰ法，对５３例不同胎龄的人胚胎小肠的亮氨酸脑啡肽（Ｌ－Ｅｎｋ）、Ｐ物质（ＳＰ）、神经肽Ｙ（ＮＰＹ）、降钙素基因相关肽（ＣＧＲＰ）、血管活性肠肽（ＶＩＰ）和甘丙素（ＧＡＬ）等６种肽能神经的发生发育过程进行观察，并与ＡＣｈ能神经和膀胱的肽能神经的发生做了对比研究。结果表明，人胚胎小肠神经中ＡＣｈ能神经发生早于肽能神经；同一个体不同器官肽能神经并非同时发生。本文观察到的小肠肽能神经的

ONTOGFNY OF 6 TYPES OF PEPTIDERGIC NFRVESOF SMALL INTESTINE IN HUMAN FETUSES

he 6 types of peptidergic innervation (L-Enk. NPY, SP, VIP, GaL) end Ach-ergicnerves of small intestine in 53 human fetuses with gestational ages ranged from 8 to 40 weekswere studied by immunocytochemistry and histochemistry , and the resuts were compared withthe peptidergic nerves of urinary bladder in human fetuses.The results indicated that the ontogeny of Achergic nerves is earlier (9 weeks of gestation) than that of 6 types of peptidergic nerves. The time apperance of VIP , SP , NPY , and L-Enk iseaelier (12 weeks of gestation , followed by GaL (12 weeks of gestation and CGRP (12 weeksof gestation). The peptidergic nerve fibers of urinary bladder appeared more later , as comparedwith those of intestine. The findings indicated that the ontogeny of peptidergic innervation maybe hetrochronous in diflerent organs. The time of development of peptidergic nerves found by theauthors is 1-3 weeks earlier than that of the Previous reports.