|
|||||
|
|
| 脂质体制剂影响大鼠皮肤超微结构的初步研究 | |
| 引用本文： | 颉玉胜,曾抗,徐彦春,孟全林,李国锋,李建华,谢方明,孙乐栋.脂质体制剂影响大鼠皮肤超微结构的初步研究[J].西北国防医学杂志,2004,25(2):100-102. |
| 作者姓名： | 颉玉胜 曾抗 徐彦春 孟全林 李国锋 李建华 谢方明 孙乐栋 |
| 作者单位： | 1. 解放军第473医院皮肤科,甘肃,兰州,730070 2. 第一军医大学南方医院皮肤科 3. 第一军医大学南方医院药剂科 |
| 基金项目： | 国家自然科学基金资助项目 (3 9970 680 ) |
| 摘 要： | 目的：研究脂质体制剂对大鼠皮肤超微结构的影响。方法：取健康大鼠背部皮肤，分别浸入空白脂质体混悬液、0．125％脂质体荧光素钠混悬液、PBS溶液中，8h后在H-600型透射电镜下观察皮肤超微结构的变化，以未经任何处理的同一大鼠背部皮肤作为正常对照。结果：经脂质体混悬液处理的大鼠皮肤表皮，尤其是皮肤角质层深层结构发生了明显改变，表现为角质浅层疏松，细胞问裂隙增大，电子密度增强，深层张力丝明显增多；棘层细胞胞质中板层小体增多。结论：表皮各层超微结构的改变可能与脂质体增加药物渗透性的机理有关。 |
| 关 键 词： | 脂质体 荧光素钠 皮肤 超微结构 |
| 文章编号： | 1007-8622(2004)02-0100-03 |
| 修稿时间： | 2003年12月25 |
Ultrastructural changes of rat skin induced by liposome |
|
| XIE Yu-sheng ,ZENG Kang ,XU Yan-chun ,et al..Ultrastructural changes of rat skin induced by liposome[J].Medical Journal of National Defending Forces in Northwest China,2004,25(2):100-102. | |
| Authors: | XIE Yu-sheng ZENG Kang XU Yan-chun |
| Institution: | XIE Yu-sheng 1,ZENG Kang 2,XU Yan-chun 1,et al . |
| Abstract: | Objective: To study the effect of liposome suspension on the ultrastructure of rat skin.Methods:The rat dosal skins treated by liposome suspension, 0.125% liposome sodium fluorescein or PBS solution for 8 hours were observed under H-600 transmission electron microscope respectively. The untreated skin of same rat was used as control. Results:The ultrastructure of stratum corneum was changed obviously, especially in deep layers where the stratum corneum loosed, the intrecellular spaces enlarged and the electric density and tonofllaments increased. The amount of lamellar bodys in prickle cells was increased]Conclusion: The ultrastructural changes of rat epidermis is associated with the permeability-increasing function of liposome. |
| Keywords: | Liposome Sodium fluorescein Skin Ultrastructure |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |