| 水杨酸钠致耳蜗电生理改变 |
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| 引用本文： | 张思毅,Don Robertson. 水杨酸钠致耳蜗电生理改变[J]. 临床耳鼻咽喉头颈外科杂志, 2003, 17(9): 551-553 |
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| 作者姓名： | 张思毅 Don Robertson |
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| 作者单位： | 1. 广东省人民医院耳鼻咽喉科,广州,510100
2. 澳大利亚西澳大学医学院生理系听力实验室 |
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| 摘 要： | 目的：了解水杨酸钠对耳蜗功能的影响，探讨其可能的作用机制。方法：采用水杨酸钠在活体豚鼠耳蜗进行灌注，同时监测豚鼠耳蜗电位中的复合动作电位(CAP)和总合电位(SP)的阈值及输入输出曲线变化，对耳蜗功能进行评估。结果：水杨酸钠可引起CAP和SP阈值同步改变，两者的变化呈一一对应关系。结论：水杨酸钠主要作用于耳蜗外毛细胞，通过影响外毛细胞的能动作用而影响耳蜗功能。
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| 关 键 词： | 水杨酸钠 耳蜗灌注 耳蜗电位 |
| 文章编号： | 1001-1781(2003)09-0551-03 |
| 修稿时间： | 2003-01-30 |
The electro-physiological change of guinea pig cochlea caused by intracochlear perfusion of sodium salicylate |
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| Don Robertson. The electro-physiological change of guinea pig cochlea caused by intracochlear perfusion of sodium salicylate[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2003, 17(9): 551-553 |
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| Authors: | Don Robertson |
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| Affiliation: | Department of Otolaryngology, Guangdong Provincial People's Hospital, Guangzhou 510100. |
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| Abstract: | OBJECTIVE: To investigate the way how sodium salicylate affects cochlear function and discuss its possible mechanism. METHOD: Sodium salicylate was perfused through guinea pig cochlea. The thresholds and input-output (I/O) functions of compound action potential (CAP) and summating potential (SP) were monitored during the perfusion. RESULT: Sodium salicylate caused a significant change of CAP and SP threshold as well as I/O curve. The relationship between CAP and SP threshold change at 10 kHz during perfusion with 10 mmol/L salicylate tends to be 1:1. CONCLUSION: Outer hair cells are most likely to be the sites of action of sodium salicylate and this action on the outer hair cell active process might lead to its ototoxicity. |
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| Keywords: | Sodium salicylate Intracochlear perfusion Cochlear potentials |
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