Comparison of whole-cell versus acellular pertussis vaccine effectiveness in school clusters of pertussis,France, 2013 |
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| Institution: | 1. Unité des infections respiratoires et vaccination, direction des maladies infectieuses, santé publique France, Saint-Maurice, France;2. Centre national de référence de la coqueluche et autres bordetelloses, institut Pasteur, Paris, France;3. Cellule Auvergne-Rhône-Alpes, direction des régions (DiRe), santé publique France, Lyon, France;4. Cellule Grand Est, DiRe, santé publique France, Nancy, France;5. Cellule Normandie, DiRe, santé publique France, Rouen, France;6. Cellule Occitanie, DiRe, santé publique France, Montpellier, France;7. Cellule Provence-Alpes-Côte-D’azur et Corse, DiRe, santé publique France, Marseille, France |
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| Abstract: | Objectives and methodWe conducted a prospective study in 2013 to compare the whole-cell versus acellular pertussis vaccines effectiveness and duration of protection, following the occurrence of pertussis clusters.ResultsDuring seven school outbreaks, we identified 102 clinical pertussis cases, including 10 cases biologically confirmed by Bordetella pertussis specific PCR, among a cohort of 305 children in 2nd to 6th grade. The risk of pertussis when vaccinated with an acellular vaccine alone was 1.6 (RR = 1.6; 95% CI = 1.1–2.5) times higher than when vaccinated with a whole-cell vaccine or using a combined schedule.ConclusionsThe limited duration of protection conferred by the acellular vaccine reinforces the 2013 introduction of the pertussis booster at six years old. |
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| Keywords: | Pertussis Vaccine effectiveness School outbreaks Whole-cell pertussis vaccine Acellular pertussis vaccine |
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