Simultaneous metastasized primary unknown signet ring cell carcinoma of the cervical lymph node and mucoepidermoid carcinoma of the parotid gland as double cancers |
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| Institution: | 1. Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachiojishi, Tokyo 193-0998, Japan;2. Department of Clinical Oncology, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachiojishi, Tokyo 193-0998, Japan;3. Department of Pathology, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachiojishi, Tokyo 193-0998, Japan;4. Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan;1. The University of Texas, M.D. Anderson Cancer Center, Department of Pathology, United States;2. Baylor College of Medicine, Department of Pediatrics, Texas Children’s Cancer and Hematology Centers, United States;3. The University of Texas, M.D. Anderson Cancer Center, Department of Genetics, United States;4. The University of Texas, M.D. Anderson Cancer Center, Department of Head and Neck Surgery, United States;1. Department of Head and Neck Surgery, Miyagi Cancer Center, Natori, Miyagi, Japan;2. Department of Plastic and Reconstructive Surgery, Miyagi Cancer Center, Natori, Miyagi, Japan;3. Department of Diagnostic Radiology, Miyagi Cancer Center, Natori, Miyagi, Japan;4. Department of Otorhinolaryngology, Head and Neck Surgery, Tohoku University School of Medicine, Miyagi Japan;1. Laboratory of Signals and Electronic Systems, Electrical and Computer Engineering Faculty, K.N. Toosi University of Technology, Tehran, Iran;2. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;1. Department of Head Neck and Thyroid, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, PR China;2. Department of Oral Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China;1. Departamento de Ingeniería Química, Universidad del País Vasco UPV/EHU, Apartado 644, 48080 Bilbao, Spain;2. Departamento de Ingeniería Minera y Metalúrgica y Ciencia de los Materiales, Universidad del País Vasco UPV/EHU, Nieves Cano 12, 01006 Vitoria-Gasteiz, Spain;1. Department of Genitourinary Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia;2. Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash Partners Comprehensive Cancer Consortium, Monash University, Melbourne, Australia;3. The Sir Peter MacCallum Department of Oncology, University of Melbourne, Australia |
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| Abstract: | Lymph node metastasis from signet ring cellcarcinoma (SRCC) primary unknown is extremely rare. We here report a case of primary-unknown SRCC that metastasized to the cervical lymph nodes, co-existing with mucoepidermoid carcinoma (MEC) of the parotid gland as a simultaneous double cancer. A 68-year-old female patient with right swollen cervical lymph nodes consulted our medical center. A diagnosis of bilateral cervical lymph node metastasis and a right parotid tumor was made. After bilateral neck dissection and right parotidectomy, the pathological diagnosis was SRCC of primary unknown with metastasis to the cervical lymph node and MEC of the parotid gland. Examination of the CRTC1/3-MAML2 fusion gene showed no relation between SRCC of primary unknown with metastasis to the cervical lymph node and MEC of the parotid gland. Ten months after the first treatment, there was recurrence in the left neck lymph node, and left neck dissection was performed. Fourteen months after the first treatment, the patient is alive and cancer-free. This case is the fourth report of SRCC with lymph node metastasis, and highlights the value of fusion gene detection to determine relatedness between simultaneous cancers. Moreover, such cases should be closely monitored for the subsequent appearance of distant metastases. |
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| Keywords: | CRTC1/3-MAML2 fusion oncogene Mucoepidermoid carcinoma Signet ring cell carcinoma |
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